Current Issue : Year : 2024 – Volume: 14 Issue: 2

 

Current Issue

Year : 2024 – Volume: 14 Issue: 2

Current Issue Articles

Original Research Article

HISTOPATHOLOGICAL TYPES AND CLINICAL PROFILE OF PRIMARY LUNG CANCER DIAGNOSED IN A TERTIARY CARE CENTRE IN KERALA –A CROSS SECTIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.1

Ok Mani, Safa VP

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Background: The second most common cancer and the main cause of death from cancer worldwide is lung cancer. The stage of the cancer, mutation, and histological type all affect the prognosis and course of treatment. There is no adequate data about histological subtypes lung cancer in our area. The aim of this study is to evaluate the smoking status, histological subtypes, clinicoepidemiological profile, and interdependencies among those suffering from lung cancer. Materials and Methods: This cross-sectional study was conducted in Department of Pulmonary Medicine, Government Medical College, Thrissur, Kerala, India. From May 2, 2021, until May 7, 2022. Histopathologicaly confirmed lung cancer patients were studied. The data was collected by using a semi-structured proforma, and SPSS 20 was used for analysis. Results: The mean age of the patients (n=124) was 63.42 + 9.11 (SD) years. The common symptoms were cough (71.8%), breathlessness (62.9%), chest pain (35.5%), and loss of weight (31.5%). Among the patients 86.3% are males and 80.6% are smokers. Adenocarcinoma was the commonest histopathological subtype (45.9%) followed by squamous cell carcinoma (37.9%), small cell carcinoma (10.5%) and other neuroendocrine tumors (5.6%). Squamous cell carcinoma was the commonest subtype among males (42.1%) and smokers (44.6%). Adenocarcinoma remained commonest among females (82.3%) and non-smokers (87%). Cough was significantly higher in squamous cell and small cell carcinomas (p=0.04). Dyspnea remained the most prevalent symptom in adenocarcinoma (64.9%). Conclusion: Adenocarcinoma was the commonest subtype. Squamous cell carcinoma had higher prevalence among males and smokers; adenocarcinoma was higher among females and non-smokers. The commonest symptom was cough. Cough was significantly higher in squamous cell and small cell carcinomas. Dyspnoea was the most prevalent symptom in adenocarcinoma. Keywords: Lung cancer, Smoking, Adenocarcinoma, Squamous cell carcinoma, small cell carcinoma.

Page No: 1-8 | Full Text

 

Original Research Article

HISTOPATHOLOGIC SPECTRUM OF INFECTIOUS SKIN LESIONS IN A TERTIARY CARE HOSPITAL IN THE GARHWAL REGION

http://dx.doi.org/10.5530/ijmedph.2024.2.2

Anamika Singh, Pawan Bhat, Sachan Bhat

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Background: Skin is the largest organ of the body and is constantly harmed by a variety of environmental factors resulting in various kinds of neoplastic and non-neoplastic skin lesions. Among the non-neoplastic skin lesions, infective skin lesions are very commonly encountered in India, possibly due to the hot and humid environment, and lack of general awareness regarding infectious diseases. Very few studies, if any, have been conducted in the Garhwal region regarding infective skin lesions. Hence, present study was carried out to determine the spectrum of infective skin lesions. Aim and Objective: Present study was carried out to understand the spectrum of various skin lesions in correlation with age, sex and type of clinical lesion at a tertiary care hospital in Garhwal region. Materials and Methods: Study Design: Non-interventional, cross-sectional, retrospective study was carried out from January 2022 to December 2023, on all skin biopsies diagnosed as infective skin lesions in the department of pathology, Veer Chandra Singh Garhwali institute of medical sciences and research irrespective of age and sex. Results: Out of the 63 cases studies, leprosy was the most common infective skin lesion followed by tubercular dermatoses. Male predominance was present, with the most commonly encountered age group being 41-50 years. Presence of a hypopigmented patch was the most common clinical finding. Conclusion: Leprosy was the most common infective skin lesion encountered in our study followed by tubercular dermatoses. Due to the wide range of clinical presentation in infective skin diseases, histopathological examination is necessary to make an accurate diagnosis. Keywords: Infective skin lesions, leprosy, tubercular dermatoses.

Page No: 9-13 | Full Text

 

Original Research Article

COMPARATIVE ANALYSIS OF LAPAROSCOPY AND LAPAROTOMY FOR MANAGEMENT OF ABDOMINAL TRAUMA: A RETROSPECTIVE STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.3

Avadhesh Ramanuj, Sanjay Karangiya, Bhavikkumar Ishvarbhai Pateliya, Mitesh Varsangbhai Chavda

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Introduction: The utilization of laparoscopy in managing abdominal trauma, either diagnostically or therapeutically, has been on the rise. However, its comparative outcomes with conventional laparotomy, especially concerning therapeutic management, remain unclear. Methods: This retrospective cohort study involved patients from trauma center of an Indian medical college. 78 patients who underwent laparoscopic interventions for abdominal trauma were included in the laparoscopy group (LP group). Another 78 patients who underwent laparotomy (LT group) were matched based on baseline characteristics, causes of injury, and hemodynamic parameters. Perioperative clinical parameters and short-term survival were compared between these two groups. Results: Baseline characteristics were similar between the LP and LT groups. The most common cause of trauma was traffic accidents, and the predominant surgical intervention was bowel repair/resection. Operation time did not significantly differ between the two groups, while the post-operative complication rate was slightly lower in the LP group without statistical significance. Opioid use was lower in the LP group compared to the LT group. Additionally, hospital stay was significantly shorter in the LP group. One patient in the LT group died due to an intra-abdominal abscess and multiple organ dysfunction syndrome 20 days postoperatively, whereas all patients in the LP group recovered and were discharged. Conclusion: Laparoscopy is deemed feasible and safe for treating hemodynamically stable abdominal trauma patients when performed by experienced surgeons. Laparoscopy appears to offer advantages such as reduced pain and quicker recovery while maintaining similarly favorable clinical outcomes compared to conventional laparotomy. Keywords: Abdominal trauma, hemodynamically stable, laparoscopy, laparotomy

Page No: 14-17 | Full Text

 

Original Research Article

THE SIGNIFICANCE OF LIPID PROFILE AND POSITIVE TROPONIN-I IN PREDICTING CARDIAC EVENT

http://dx.doi.org/10.5530/ijmedph.2024.2.4

Pal Singh Yadav, Ajay Kumar Meena, Rishi Ram Meena

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Background: Cardiac troponins (cTn) are specific biomarkers of myocardial injury and have a well-established role in guiding the management of chest pain.5,6 An elevated troponin-I (cTnI) has also been associated with a poor prognosis in critical illness, pulmonary embolism, cardiac and non-cardiac surgery, stroke, and end-stage renal disease. Materials and Methods: This study was conducted in Department of Medicine in RBM Hospital & Shree Jagannath Pahadia Medical College, Bharatpur, Rajsthan. This cases control study was included 100 control and 250 cases. The duration of study was over a period of one year. Results: Among the 250 cases examined, 96 tested positive for Troponin-I, while the remaining cases tested negative. Among the Troponin-I positive cases, 64 were male and 32 were female, indicating a higher predominance of Troponin-I positivity among males. Significant differences (p < 0.01) were observed in these variables between the cases & control groups. Conclusion: The present study shows in the patients who developed chest pain due to cardiac event as confirmed by positive troponin-I test were having lipid parameters in the risk level as suggested by ATP III. Keywords: Troponin-I (cTnI), Myocardial injury, Biomarkers.

Page No: 18-21 | Full Text

 

Original Research Article

CLINICO-SOCIAL FACTORS ASSOCIATED WITH TUBERCULOSIS AND DIABETES MELLITUS COMORBIDITY IN SOUTH INDIA – A CASE- CONTROL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.5

Praveen G S, Sanjay S Kambar, Sajna M V, Binu Areekal

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Background: Despite control strategies, tuberculosis remains a significant public health problem in many countries. Along with effective control measures currently available, it is essential to identify and target the risk factors of developing active TB to tackle the heavy burden of the disease. This study aims to find out the association of clinical and social factors with Tuberculosis and Diabetes mellitus co-morbidity. Materials and Methods: A case-control study was done to assess the association of clinical and social factors with Tuberculosis and Diabetes mellitus co-morbidity. The study was done from a parent study conducted in South India to study the prevalence of diabetes mellitus among registered tuberculosis patients. Those patients diagnosed with both tuberculosis and diabetes mellitus were taken as cases, and those patients with tuberculosis without diabetes mellitus were taken as controls. Cases and controls were above the age of 15 years. The calculated sample size was 115:345, as there were only 92 cases in the parent study. All were taken. Social factors like age, gender, occupation, and socio-economic status, as well as clinical factors like various symptoms, symptom score, type of tuberculosis, category, and treatment outcome, were studied in this study. Data was coded in Excel and analyzed using SPSS version 16. Chi-square analysis was done to find out the association and odd’s ratio. Results: There was a significant difference in age between cases and controls. All symptoms are significantly higher (Chi-square 27.6p-0.0001) among those who have tuberculosis and diabetes co-morbidity when considering each symptom separately. Extrapulmonary tuberculosis was found more among controls. In this study, it was found that relapse and treatment after default were significantly higher among cases(Chi square 23.4 p-0.000034). Conclusion: A significant difference was found among TB patients with DM as co-morbidity when compared with patients without DM. Uncontrolled diabetes will be one challenge for TB elimination. Hence, periodic screening is necessary to find out DM and the proper measures to be followed to control. Keywords: Diabetes co-morbidity, Symptom score, treatment outcome.

Page No: 22-25 | Full Text

 

Original Research Article

TO EVALUATE THE INTERPERSONAL SKILLS OF INTERNS IN ORTHOPEDICS USING MINI-CLINICAL EVALUATION EXERCISE – AN INTERVENTIONAL STUDY FROM NORTH INDIA

http://dx.doi.org/10.5530/ijmedph.2024.2.6

Kuldip Singh Sandhu, Ashim Sharma, Affia Sachdeva, Annie Sandhu, Daljinder Singh

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Background: Medical undergraduates having lack of interpersonal skills may lead to severe deficiencies in health services. Currently these were not being trained or assessed at workplace for their behavior and communication skills during their medical curriculum. During this study, mini-CEX (mini clinical evaluation exercise) was used as a work place based assessment (WPBA) tool to assess the interpersonal skills of interns and providing them concurrent feedback. The aim of this study was to evaluate and improving the interpersonal skills of interns posted in orthopedic department during their rotatory internship while assessing the acceptability, feasibility and effectiveness of mini-CEX assessment as a tool. Materials and Methods: This prospective and interventional study was conducted in department of orthopedics of our hospital settings between July to November of 2022. The forty interns who participated in this study were on rotatory internship in our department and 06 volunteered faculty members were also included. The mini-CEX form as assessment tool structured by American Board of Internal Medicine was used in this study. Each intern undergone six rotatory assessment sessions, on mini-CEX forms with each of the faculty comprising a total of 240 sessions. Participants at the end of their internship submitted their perceptions on an anonymous validated questionnaire which contains both open ended and closed ended questions (Likert 5-point scale). Statistical Analysis: The descriptive data having frequencies were analyzed using Microsoft Excel software. Thematic analysis was used for qualitative data of open ended questions. Results: Most of interns (36/90%) and all included faculty members had shown that mini-CEX assessment tool has encouraged them and helpful in improving their communication skills. On comparison of their first through 6th encounters, interns had shown improvement in their mean min-CEX score for skill development and competencies with improvement in communication skills. This improvement was statistically significant. (p<0.05). Conclusion: Our study had shown that mini-CEX as WBPA too is an acceptable, effective as well as feasible method for assessing the interpersonal skills of interns in clinical settings. Keywords: interns, interpersonal, encounters, skills.

Page No: 26-31 | Full Text

 

Original Research Article

A STUDY OF EFFICACY AND ROLE OF TERIPARATIDE(rh-PTH) THERAPY IN SURGICALLY CORRECTED COMMINUTED FRACTURES AT A TERTIARY CARE CENTER

http://dx.doi.org/10.5530/ijmedph.2024.2.7

Raju Dande, Rajendar Reddy B, Mohammed Faisal, Sannith Kumar Korutla

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Background: To study the efficacy of teriparatide therapy in surgically corrected comminuted fractures. Materials and Methods: Prospective observational study was conducted in 50 patients of either gender who are skeletally mature presenting with comminuted fracture or nonunion after surgical correction, without comorbidities who are medically fit for taking the teriparatide are included in study. Results: One third of the patients belonged to the age group of 30-39 years and 40-49 years. 82% of the study population were males, 18% of them were females. 70% of the study population were injured on the right side, 30% of them were injured on the left side. 76% of the study population lower limbs were injured, 30% of them had injury on the upper limbs. 74% of the study population had Road Traffic Accident. 36% of the study population had fracture of femur. 6% of them had fracture of both tibia and fibula. 2% of them had fracture of both radius and ulna. Only one patient had fracture neck of humerus. 42% of the study population showed signs of radiological union after 3-4 months of drug administration, followed by within 3 months (30%), 5-6 months (20%). 92% of the study population had achieved complete radiological union at the end of one year follow up. 44% of the study population showed complete radiological union after 7-9 months of drug administration. Complete range of movements was achieved in 52% of the study population. The range of movements was increased in 40% of the study population. 8% of the study population had restricted movements at the end of the study period. 56% of the study population had experienced side effects. 52% of the study population had nausea, 28% of them had dizziness and 18% had hypercalcemia. Conclusion: The present study concluded that the efficacy of teriparatide in surgically treated comminuted fracture healing cases is 92%. The drug was tolerated well with minor side effects like nausea and dizziness. Keywords: Teriparatide, comminuted fracture, Radiological union.

Page No: 32-39 | Full Text

 

Original Research Article

A STUDY OF PREVALENCE OF APPENDICOLITH AND ITS ASSOCIATION WITH SEVERITY OF APPENDICITIS

http://dx.doi.org/10.5530/ijmedph.2024.2.8

Manas Ranjan Pattnaik, Suveer Bhargava, Ravindra Singh

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Background: Acute appendicitis is one of the most frequent cause of pain abdomen. Acute Appendicitis can present as complicated or uncomplicated. Complication are abscess, gangrene, perforation. Most common cause of Appendicitis is luminal obstruction by appendicolith. Appendicolith is also known as faecolith/ stercolith/ coproliths is composed of faecal concretions or pellets, calcium phosphates, bacteria and epithelial debris and can lead to luminal obstruction followed by appendicitis. They are seen in 10% of patient with acute appendicitis. Objective: To study any association between appendicolith and its effect on recovery of patient with appendicitis. Materials and Methods: This is prospective study carried out from January 2021 to December 2023 in Command Hospital and Military hospital Jammu in all patients of Acute Appendincitis. Data was collected in terms of age, sex, presentation, TLC score, USG/CT, Mantrls score, surgery done, intra op finding, appendicolith seen or not and histopathology. Results: Out of 170 patients who underwent appendicectomy, 139 patients were more than 20 years of age (81%). Following appendicetomy, appendicolith was found 33patient (19.41%).11 patients were less than 20 years of age (33%).There were 36 female patients (21%) of appendicitis.139 patient presented in acute phase (82%) and operated upon. Rest were operated as cold cases as int appendicectomy. Lap appendicectomy was done in 143 cases (84.1%). Rest was open appendicectomy. Acute appendicitis was found in 9 cases with appendicolith (33%).Complicated appendicitis was found in 24 cases with appendicolth (72.7%). Conclusion: Appendicolith is commonly present in more than 20-year age group. Mantrls score is higher in appendicitis with appendicolith. TLC is also more than 10000 in majority of patients with appendicolith. Majority patient presented in acute stage and were operated upon. Presence of appendicolith was associated with higher TLC, higher Mantrls score and complicated intraop and HPE finding. Keywords: Acute appendicitis, Appendicolith, TLC, HPE finding, HPE finding.

Page No: 40-42 | Full Text

 

Original Research Article

COMPARATIVE EVALUATION OF PROPOFOL KETAMINE AND PROPOFOL FENTANYL IN ERCP/ENDOSCOPIC PROCEEDURES

http://dx.doi.org/10.5530/ijmedph.2024.2.9

Sangeeta Chauhan, Krishna Kumar Tripathi

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Background: Aims: To find the ideal drug combinations which can be used during day care surgeries and procedures. This study was conducted to valuate and compare the efficacy, and haemodynamic stability of ketamine and entanyl combination with propofol. Also compared were the incidence of side effect, the time of awakening and recovery time. The discharge criteria in both groups was also compared. Materials and Methods: The study was conducted in 50 patients of age group 18-50 years of either gender belonging to ASA grade I or II, were divided into two groups of 25 each. They underwent elective ERCP of approximately 1 hour duration. Group I received Propofol- ketamine while group II received Propofol-fentanyl for induction and maintenance of anaesthesia. Postoperatively, time for awakening, recovery time ‘(by modified Aldrete scoring system) and discharge status (by modified post anaesthetic discharge scoring system) were recorded and compared in two groups. Results: Profol-fentanyl combination produced a significantly greater fall in pulse rate and in both systolic and diastolic blood pressure as compared to Propofol-ketamine during induction and maintenance of anaesthesia. Fall in respiratory rate was greater in Propofol- fentanyl group as compared to Propofol-ketamine group. The recovery time in group II was longer than group I. Discharge criteria is significantly earlier in group I. Conclusion: Both Profol- ketamine and Propofol-fentanyl combination reduce rapid, pleasant and safe anesthesia with only a few untoward side effects and propofol-ketamine produces better haemodynamic statistic, during anaesthesia, but recovery and smooth discharge was seen with propofol fentanyl group. Keywords: Propofol, Fentanyl, Ketamine, Day care surgery, ERCP, Endoscopic proceedures.

Page No: 43-48 | Full Text

 

Original Research Article

COMPARATIVE EFFICACY OF DEXMEDETOMIDINE AND CLONIDINE IN CARDIAC VALVULAR SURGERIES: A PROSPECTIVE RANDOMIZED CONTROLLED STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.10

S. Syed Mohammed Jazeel, S. Dhivakar, Vivekanandhan.N, Sri Hari Vignesh R

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Background: Dexmedetomidine and Clonidine, both α2-adrenergic agonists, are commonly used in cardiac surgery for their hemodynamic stabilizing properties. However, comparative data on their efficacy in cardiac valvular surgeries remain limited. Materials and Methods: We conducted a prospective randomized controlled study involving 60 patients undergoing elective cardiac valvular surgeries between September 2019 and August 2020. Patients were randomized to receive either Clonidine or Dexmedetomidine. Intra-operative hemodynamics, anesthetic requirements, and post-operative recovery times were compared between the two groups. Results: Dexmedetomidine demonstrated superior efficacy in reducing heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure compared to Clonidine. Patients receiving Dexmedetomidine required lower doses of inhalational anesthetics, opioids, and muscle relaxants. Additionally, Dexmedetomidine was associated with shorter durations of mechanical ventilation (398.00 ± 51.47 vs. 475.67 ± 35.15 minutes, P < 0.0001) and length of stay in the post-operative ICU (53.90 ± 3.75 vs. 60.60 ± 3.78 hours, P < 0.0001) compared to Clonidine. Conclusion: Dexmedetomidine offers superior intra-operative hemodynamic stability, reduced anesthetic requirements, and faster post-operative recovery compared to Clonidine in patients undergoing cardiac valvular surgeries. Keywords: Dexmedetomidine, Clonidine, Cardiac surgery, Hemodynamics, Anesthetic requirements, Post-operative recovery.

Page No: 49-55 | Full Text

 

Original Research Article

A STUDY ON UTILIZATION OF HEALTH APPLICATIONS AND ITS AWARENESS AMONG PEOPLE

http://dx.doi.org/10.5530/ijmedph.2024.2.11

Koppala Ravi Babu, Gnanasekar Thirugnanam, Siral Hegde, Erukula Ramanjaneyulu

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Background: Mobile health applications are a relatively new phenomenon in the healthcare industry, but their use is expanding rapidly for both general health and specific medical needs. Objective: To compare the utilization of the health apps among patients visiting pharmacies and health stores hospital and it awareness among people. Materials and Methods: A cross-sectional descriptive study was conducted with the general population who were using mobile health apps in the state between January 2023 to June 2023. The participants in the study were recruited from retail pharmacies and health stores located in different areas in the cities. Clients visiting the pharmacies and health stores were approached and invited to participate in the study, and those who agreed were interviewed. The inclusion criteria included smartphone owners who were using health-related apps, of age ≥ 18 years old, and those who could speak the English language. Results: Out of 270 individuals, 52% of the sample were male and 48% were female, and the mean age (SD) of participants was 29.74 (11.74). In this study, 31% of the participants reported using their health apps on a daily basis, 40% at least once weekly, and 25% monthly. The main benefits of mobile health apps were tracking of health status (49%), followed by motivation (24%) and gaining knowledge about health and fitness (20%). The main issues reported by the participants included inaccuracy of the app (12.5%), inconvenience (5%), and not being user-friendly (8%). Conclusion: These apps inspired the participants to keep up their wellbeing and exercise while assisting them in tracking and better managing their health. To ensure evidence-based and efficient app use to achieve the desired health outcomes, further opportunities for improvement have been found. Keywords: Digital health, digital patients, health apps, mhealth, teleconsultation.

Page No: 56-59 | Full Text

 

Original Research Article

COMPARISON BETWEEN DEXMEDETOMIDINE AND ESMOLOL AS EFFECTIVE PRETREATMENT REGIMENS ON ATTENUATION OF HAEMODYNAMIC PARAMETRES DURING ELECTROCONVULSIVE THERAPY

http://dx.doi.org/10.5530/ijmedph.2024.2.12

Altafuddin Ahmed, Alangkrita Sarmah, Jyostna Dutta, Hilan Chakrabarty

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Background: Modified Electroconvulsive Therapy (ECT) under anesthesia is an important modality in the treatment of severe persistent depression, bipolar disorder and schizophrenia; specially in case resistant to pharmacological therapy; but this procedure has got many side effects, specifically the hemodynamic alteration is markedly observed. Aim: The aim of present study to compare between Dexmedetomidine and esmolol as effective pretreatment regimens on attenuation of hemodynamic parameters during electroconvulsive therapy. Materials and Methods: After getting approval of the study protocol by the institutional ethics committee (H) of Assam Medical College and Hospital, Dibrugarh and getting written informed consent from the patients and their relatives, fifty cases aged between 20-40 years belonging to ASA grade I and II scheduled for ECT are included in the study and grouped in 2 groups of 25 patients each. Group E received IV esmolol 1mg/kg body weight diluted up to 10ml of normal saline and infused within 2 minutes as premedication. Group D received IV Dexmedetomidine 0.5 mcg/kg diluted to 10ml of normal saline and infused within 10 minutes as premedication. Hemodynamic parameters heart rate (HR), systolic blood pressure, diastolic blood pressure and mean blood pressure at baseline (before induction), after study drug infusion and after ECT application were recorded at different time intervals and presented along with demographic data. Statistical analysis was done with SPSS software using student t-test and Chi square test. Results: In this study, the baseline systolic blood pressure, diastolic blood pressure and mean blood pressure was statistically insignificant. The heart rate(HR), systolic blood pressure(SBP) and diastolic blood pressure(DBP) was significantly decreased in both esmolol and Dexmedetomidine group after drug administration and at 1,3,5 and 10 min post ECT shock. However, the decrease in MAP was statistically insignificant in both the groups after premedication, at 1,3,5,10 minutes of delivery of ECT shock. The mean time of return of spontaneous respiration was statistically insignificant. Conclusion: Based on the present hospital based observational study, we came to the conclusion that an intravenous premedication agent in ECT, both esmolol at a dose of 0.1 mg/kg and Dexmedetomidine at a dose of 0.5 mcg/kg results in attenuation of cardiovascular (HR, BP, MAP) effects but more reduction of hemodynamic parameters were seen in the Dexmedetomidine compared to esmolol. The mean blood pressure however was unaffected. Keywords: Dexmedetomidine, esmolol, modified Electroconvulsive therapy, hemodynamic parameters.

Page No: 60-63 | Full Text

 

Case Report

A RARE CASE OF RETROPERITONEAL LIPOSARCOMA COMPLICATED WITH GIANT COLONIC DIVERTICULUM: CASE REPORT

http://dx.doi.org/10.5530/ijmedph.2024.2.13

Amitabh Goel, Vandana Bansal, Laalji Patel, Sonal Nivsarkar, Dolly Mehta, Sana Afrin, Saranshi Shrivastava, Rahul Patidar

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The co-occurrence of retroperitoneal liposarcoma and a giant colonic diverticulum poses diagnostic challenges due to their uncommon nature and overlapping clinical presentations. Here, we present a unique case report of a 76-year-old female with hypertension and myasthenia gravis who presented to Vishesh Jupiter Hospital, Indore and diagnosed with retroperitoneal liposarcoma complicated by a giant colonic diverticulum detailing its presentation, diagnostic journey and management strategies. Keywords: Retroperitoneal liposarcoma, Giant Colonic Diverticulum.

Page No: 64-69 | Full Text

 

Original Research Article

TO COMPARE EFFICACY OF LAPAROSCOPIC CHOLECYSTOSTOMY AND INTERVAL CHOLECYSTECTOMY VERSUS OPEN CHOLECYSTECTOMY IN CASES OF DIFFICULT GALLBLADDER

http://dx.doi.org/10.5530/ijmedph.2024.2.14

Krishna Chowdary Amirineni, Niharika Adusumilli, Rao Haneesha, Kola Praveen kumar, S B J L Harshini5, R Indu

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Background: To evaluate and compare efficacy of laparoscopic cholecystostomy and interval cholecystectomy versus open cholecystectomy in cases of difficult gallbladder. Materials and Methods: This study will be conducted in Department of General surgery, Kamineni Hospital, Hyderabad between October 2012 to December 2014. The facilities, expertise and the necessary Infrastructure are available in this hospital. A comparative observational study, which included 40 patients of difficult gallbladder who needs cholecystectomy. Ethics committee’s permission has been taken. Results: In the present study, there were difficulties associated with Laparoscopic cholecystostomy like subjecting the patient to a second surgery, carrying a drain, longer hospital stay and increased expenditure. Laparoscopic cholecystostomy followed by Interval chole- cystectomy was safe with less postoperative morbidity associated with faster patient recovery and satisfaction as documented by less postoperative pain, earlier resumption of oral feeds, earlier full mobilization and discharge home, as well as lesser complication rate with least possible scar. Conclusion: In conclusion, the study supports the view that laparoscopic cholecystostomy followed by interval cholecystectomy is safer and efficacious and offers definitive advantages over open conversion and should be an available option for all patients requiring emergency cholecystectomy. Keywords: Cholecystectomy, Laproscopic, Gall Bladder, VAS, Postoperative.

Page No: 70-75 | Full Text

 

Original Research Article

ROLE OF NEBULISED HYPERTONIC SALINE IN THE TREATMENT OF ACUTE BRONCHIOLITIS IN CHILDREN AGED 4 WEEKS TO 2 YEARS

http://dx.doi.org/10.5530/ijmedph.2024.2.15

Ritesh Veerlapati, Soma Santosh Kumar

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Background: To study the effect of nebulised 3% saline on hospitalized children aged 4weeks to 2 years with acute bronchiolitis with regard to decrease in respiratory distress and duration of hospital stay. Materials and Methods: This was a hospital based prospective interventional non blinded controlled trial done in the age group of 4 weeks to 2 yrs admitted with acute bronchiolitis with a Respiratory Distress Assessment Instrument (RDAI)score of 4 to 15 [on a scale of 0 (mild) to 17 (severe)] in a teritiary care centre. Results: The most common presenting complaint in our study was cold which was present in 43 (76.79%) cases followed by cough in 41 (73.21%). This was followed by hurried breathing in 31 (55.36%). Wheeze was present in 29(51.79%) cases and fever in 28 (50%). The two groups were comparable with respect to baseline characteristics. The number of children who improved with treatment in Study group was 19(63.3%) and in control group was 11(36.70%). When compared to control group, there was statistically significant (p=0.015) improvement in the study group. This showed that the nebulised 3% saline nebulisation was useful in symptomatic improvement in the clinical condition of significantly more number of children. There was significant reduction in RDAI scores and improvement in saturation after 6hr, 12hr and 24hrs of initiation of treatment in Study group. Conclusion: The present study concluded that there was significant decrease in Respiratory rate and RDAI scores with the use of 3% NS nebulisation. The duration of hospital stay was less and the time required for change of treatment was more in Study group, but statistical significance could not be established. Keywords: Bronchiolities, RDAI Score, NS nebulisation, wheeze.

Page No: 76-81 | Full Text

 

Original Research Article

A STUDY ON EVALUATION OF RISK FACTORS AND OUTCOMES OF EMPYEMA THORACIS IN PEDIATRIC AGE GROUP.

http://dx.doi.org/10.5530/ijmedph.2024.2.16

Soma Santosh Kumar, Ritesh Veerlapati

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Background: Empyema thoracis is a life-threatening complication of pneumonia in children, especially below 5 years of age. The treatment outcomes depend upon the nutritional state of the child and provision of medical care to administer appropriate antibiotics. This study was done with an aim to evaluate the risk factors and outcomes of children with empyema thoracis. Materials and Methods: A total of 100 children who presented to the OPD with empyema thoracis, over a period of 18 months were included in the study. Results: Majority of the children were below 5 years of age and most of them were males. Most of the participants belonged to lower socio-economic status. Anemia was the most commonly associated risk factor. ICD was removed within 1 week. Conclusion: Early initiation of antibiotics along with ICD tube placement can allievate the immediate clinical or delayed complication. Keywords: empyema thoracis, pediatric, pneumonia.

Page No: 82-84 | Full Text

 

Original Research Article

SELF INDUCED ABORTION AMONG WOMEN ADMITTED IN A TERTIARY CARE CENTRE - A CROSS SECTIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.17

Jaya Singh, Minakshi Singh, Anil Kumar Malik, Minali Raja, Chitra Joshi, Yesvant Singh Pal

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Background: While medically supervised abortion adhering to guidelines boasts a success rate of 92-97%, the widespread availability of abortion pills over the counter has led to rampant self-administration, resulting in frequent complications. Despite the perception of unsupervised medical abortion as unsafe, many women utilize it for pregnancy termination and birth spacing. Aim of the Study: The aim of this study was to study the implications of self-administration of abortion pills by pregnant women. Materials and Methods: Retrospective cross sectional study done in Government Doon Medical College & Hospital between the period of August 2022- july 2023. Case sheets were analysed to obtain data regarding self-administration of abortion pills and complications secondary to its administration. The following data were collected- Age, marital status, parity, duration of pregnancy as perceived by the women, confirmation of pregnancy, duration between pill intake and visit to hospital, whether any intervention done elsewhere, any known medical or surgical complications, Hb level on admission, whether patient was in shock, USG find-ings, evidence of sepsis, blood transfusion, treatment given and duration of hospital stay. Descriptive analysis of the collected data was done. Results: Among the 148 cases of abortion in the study period, 75 patients had self-administered abortion pills. Among these 75 patients 26.6% had consumed abortion pills after the approved time period of 63 days of which 20% had consumed pills after 12 weeks of gestation. The most common presentation was excessive bleeding (73.33%) Severe anaemia was found in 37.33% of the patients and 8% of patients presented with shock. The outcome was as follows: 66.66% of the patients were found to have incomplete abortion, 13.33% had failed abortion and 5.22% of patients had incomplete abortion with sepsis. Surgical evacuation was performed in 33.33% of the patients whereas 46.66% of the patients required surgical evacuation with blood transfusion. Medical methods were used in 9.33% of the patients whereas 6.66% required transfusion along with medical methods. Conclusion: The study sheds light on the increasing trend of self-administered MTP pill intake among women and underscores the importance of ensuring adequate education, counseling, and support for safe and effective self-administration practices. Further research is warranted to explore the long-term outcomes and implications of self-administered MTP pill intake in diverse healthcare settings. Keywords: Medical termination of pregnancy, Maternal mortality, abortion, complications.

Page No: 85-90 | Full Text

 

Original Research Article

SERUM ZINC LEVELS AND THE SPECTRUM OF DIARRHEA IN CHILDREN (6 MONTHS TO 5 YEARS): ACUTE, CHRONIC, AND PERSISTENT PRESENTATIONS

http://dx.doi.org/10.5530/ijmedph.2024.2.18

Khushbu Rani, Manisha Kumari, Navin Kumar Sinha, Uday Kumar

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Diarrhea causes an estimated 2.5 million child deaths in developing countries each year. It is the third leading killer of children in India today and is responsible for 13% of all deaths in children less than five years of age and kills an estimated 300,000 children in India each year. Diarrhea is one of the clinical manifestations of zinc deficiency in humans. 25 children (aged 6 months-5 years) of either sex suffering from diarrhea and admitted in paediatric ward and emergency of RDJMMCH, Muzaffarpur were selected for the study. Serum zinc levels were estimated by colorimetric kit method and compared with those of 25 healthy age-matched controls. It was observed that the serum zinc levels were significantly lower in children suffering from diarrhea (39.26 ± 12.18 vs. 78.60 ± 11.63 µg/dl, p<0.05). However, there was a negligible correlation between diarrhea and gender. Thus, diarrhea is associated with an increased loss of zinc in feces so that children with diarrhea would be at an increased risk of zinc deficiency. Zinc supplementation is now being recommended by WHO, UNICEF, and countries around the world for the supportive treatment of all diarrhea episodes among children, and this should be encouraged in routine clinical practice. Keywords: Diarrhea, Zinc, Children, Deficiency, Supplementation.

Page No: 91-93 | Full Text

 

Original Research Article

PULMONARY FUNCTION TESTS IN DIABETES MELLITUS TYPE 2: A CASE CONTROL STUDY IN A TERTIARY CARE CENTRE OF UTTAR PRADESH

http://dx.doi.org/10.5530/ijmedph.2024.2.19

Yesvant Singh Pal, Deepika Tiwari, Anil Kumar Malik, D.P. Tiwari, Minakshi Singh

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Background: Diabetes is a micro-macrovascular disorder with debilitating effects on many organs. Pulmonary complications in diabetes mellitus with the loss of pulmonary reserve may become clinically important. The relationship between DM and pulmonary function tests (PFTs) remains important because of potential epidemiological and clinical implications. Aim of the Study: The aim of this study was to measure pulmonary function tests (PFTs) in diabetes mellitus type 2(DMT2) subjects and to determine the correlation of glycosylated haemoglobin (HbA1c) with pulmonary function tests inDMT2 patients. Materials and Methods: This study was conducted in the Department of Physiology, Subharti Medical College in collaboration with Department of Medicine, Chattrapati Shivaji Subharti Hospital, Meerut A total of 100 non-smoker subjects of either sex in the age group of 30-50 years were recruited. The subjects were divided into 2 groups -Group A: 50 having history ofDMT2 and Group B: 50 Normal controls. The selected patients were evaluated by taking detailed history and thorough clinical examination was done. Test for Plasma Glucose and HbA1c was done. Pulmonary function tests was done by Spirometry recording FVC, FEV1,FEV1/FVC ratio and PEFR. The data so collected was subjected to standard statistical analysis. Results: Majority of subjects were between 40-50 years while only 6 were between 50-60 years of age. The sex distribution in both cases and controls was similar. All the respiratory parameters were lesser in subjects with diabetes than non- diabetics except FEV1/FVC ratio which showed slight increase in cases than control. Statistically significant decrease occurred in FVC, FEV1 (P<0.05) & PEFR (P<0.000) while increase in FEV1/FVC ratio was statistically insignificant giving an indication about probable deterioration in lung functions in asymptomatic diabetics. Conclusion: Lung functions need to be checked periodically to assess the severity of impairment in DMT2 patients. Keywords: Pulmonary Function Tests, Diabetes Mellitus Type 2, Glycosylated haemoglobin (HbA1c), complications.

Page No: 94-98 | Full Text

 

Original Research Article

CUTANEOUS MANIFESTATIONS OF EARLY NEONATES IN A TERTIARY CARE HOSPITAL

http://dx.doi.org/10.5530/ijmedph.2024.2.20

Maripati Lavanya, Subhash Reddy Dudhipala, B Raghavendra Rao, Pranitha Raireddy

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Background: Aims: To study various cutaneous manifestations in early neonates that is within 7 days from the birth, fromAntenatal wards, dermatology outpatient department and Neonatal intensive care unit(NICU). Materials and Methods: It is a cross-sectional study including 150 neonates from OPD of Department of Dermatology, obstetrics and gynecology ward and NICU. Results: The percentage of consanguineous marriage and non – consanguineous marriage in the parents of neonates were seen as 16% and 84% respectively. The commonest cutaneous manifestations found in our study were that of pigmentary type i.e. Mongolian spot amounting to 22% of the cases most commonly over the lumbosacral region. The physiological desquamation was the commonest finding of papulosquamous changes that were seen in our study amounting to 18% of cases. The next commonest condition was of Erythema toxicum neonatorum amounting to 12% of the cases most frequently observed on the trunk. Acrocyanosis amounted to 8% of the cases in this study. The nasal lesions were demonstrated in all the cases of Sebaceous gland hyperplasia amounted to 6% of our case study. 5.3% of the cases were hypertrichosis lanugosa occurring over the shoulder, trunk and limbs. Miliaria accounted for 5.3% of the cases. It was more common in neonates admitted in NICU. Milia was found in 4% of the cases and most commonly occurred in neonates with birth weight >2.5kg. Of the solitary lesions Café au lait macules which were seen in our study amounted only to 2 %. The 2 % of cases wherein vernix caseosa seen were prominently observed in the axilla. Axillary hyperpigmentation amounted to 2 % of the cases. In our study two neonates demonstrated congenital melanocytic nevi amounting to 2 % of the cases. Other skin changes included amounting to 10 % of the total cases. Conclusion: Awareness of cutaneous manifestations in neonates helps us to differentiate between the benign transient lesions from the pathological conditions, so that timely intervention and necessary follow-up may be done where needed as well as to give assurance to the anxious parents. Keywords: Mongolian spot, papulosquamous, Erythema toxicum neonatorum, hypertrichosis lanugosa.

Page No: 99-104 | Full Text

 

Original Research Article

EFFECT OF KNOWLEDGE, PRACTICE OF MENSTRUAL, REPRODUCTIVE HYGIENE AND AVAILABILITY OF SANITARY FACILITIES ON SCHOOL ABSENTEEISM IN URBAN AND RURAL AREAS OF DEHRADUN: A COMPARATIVE STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.21

Anupama Arya, Nandini Singh, Arushi, Hem Chandra

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Background: Proper education and menstrual hygiene management facilities form a pathway for the overall growth and development of an adolescent girl. Poor availability of menstrual hygiene facilities in school can have a negative impact on the reproductive health of a girl as well as contribute to school absenteeism, sometimes resulting in school dropout. This study evaluates the various factors associated with school absenteeism during menstruation, and to assess knowledge of reproductive health. Objectives: 1. To assess the various factors affecting school absenteeism among adolescent girls. 2. To assess the availability and quality of sanitation facilities available in school washrooms 3. To evaluate the knowledge and practice of reproductive health in adolescent school going girls. Materials and Methods: A school based cross sectional study was conducted among 505 school girls urban and rural areas (Government and Private schools) in Dehradun, Uttarakhand. A semi-structured, pretested close and open-ended questionnaire was prepared in both Hindi and English language to obtain maximum results. Data Entry was done in MS excel and was analysed in SPSS software. Results: 51.56% girls in urban areas and 31.33% girls in rural areas remained absent from school during menstruation. Despite good level of knowledge of RTI/STIs 21, 48% girls in urban areas and 24.10% girls in rural areas said that they have had infection during or around menstruation. The sanitary facility in rural schools was less than that available in urban areas. Only 34.94% girls in rural areas reported of having soaps available in their school washrooms. Conclusion: Adolescent girls should be given appropriate knowledge regarding menstruation and reproductive health. This study is able to identify the lack of knowledge and hygiene facilities which can be improved in bringing them out of misconceptions and promote menstrual health and hygiene and increase the education among girls. Separate functioning sanitary facilities are necessities that should be in school at all girls empowerment and improvement in reproductive health is to be achieved. Keywords: Adolescent girls, Menstrual hygiene, Practices, School sanitation, School absenteeism, RTI, STI.

Page No: 105-110 | Full Text

 

Original Research Article

THE STUDY OF PREVALENCE OF LV DIASTOLIC DYSFUNCTION IN TYPE 2 DIABETES MELLITUS

http://dx.doi.org/10.5530/ijmedph.2024.2.22

Valarmathi S, Jayanthi N, Senthil C, Ganapathy V

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Background: The intertwined narrative of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) unfolds like a historical epic, with each chapter revealing new layers of complexity and challenge. This study aims to the prevalence ofdiastolic dysfunction in type 2 diabetes mellitus patients and to study the clinical profile of patients with diastolic dysfunction. Materials and Methods: The study was conducted on 100 patients. Patients with clinical features of acute appendicitis aged between 15 and 65 years were included in this study. he neutrophil Lymphocyte ratio would be obtained by dividing the percentage of neutrophils to the percentage of lymphocytes from the data available from differential leukocyte count. All patients was subjected to ultrasound examination of abdomen. Based on evidence in medical literature diagnostic categories for ultrasound abdomen are as follows. Results: The prevalence of diastolic dysfunction was found to be 59.37%. Within this subset, 5.3% were aged between 30 and 40 years, 17.5% were aged between 41 and 50 years, majority comprising 43.8%, were aged between 51 and 60 years, and around 33.4% were aged between 61 and 70 years. Notably, the majority of individuals with diastolic dysfunction were male, accounting for approximately 52.6% of the cases. Regarding the duration of diabetes among those with diastolic dysfunction, approximately 73.7% had been diagnosed within the past 1 to 10 years, while 22.8% had been diagnosed between 11 and 20 years ago, and only 3.5% had been diagnosed for over 20 years. Furthermore, in terms of body mass index (BMI), the majority fell within the range of 25.0 to 29.9 (50%), followed by 37.5% falling within the range of 18.6 to 24.9. The ejection fraction (EF) levels averaged 58.055.48 in the diastolic dysfunction group and 61.215.04 in the non-diastolic dysfunction group. Conclusion: The findings of this study underscore the multifaceted nature of diastolic dysfunction in the context of diabetes mellitus, emphasizing the need for comprehensive assessment and management strategies to address this significant cardiovascular complication in diabetic patients. Keywords: Ventricular dysfunction, diabetes mellitus, age, Type 2, risk factors, prevalence.

Page No: 111-115 | Full Text

 

Case Series

LUPUS NEPHRITIS IN MALES: A CASE SERIES

http://dx.doi.org/10.5530/ijmedph.2024.2.23

PL Venkata Pakki Reddy, M. Sreedhar Sharma, Soma Ananth, Aditya

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Background: The prevalence of systemic lupus erythematosus (SLE) in the general population ranges from 8 to 180 cases per 100,000 individuals. The female to male ratio varies from 6 to 13 cases in females for every 1 case in males. Several observations suggest an estrogen effect as a potential explanation for this gender difference. In children, the impact of sex hormones is assumed to be minimal, resulting in a female to male ratio of 3 to 1. We report a case series of five male patients who presented at the Kurnool Medical College, Kurnool in the state of Andhra Pradesh and were diagnosed to have lupus nephritis (LN). Male patients with SLE typically present with renal involvement and seizures rather than photophobia and skin manifestations. The prognosis for male patients also appears to be more severe. Therefore, despite the rarity of male patients with lupus, the symptoms are life-threatening, and early detection of the disease is crucial for improving patient outcomes. Keywords: Lupus Erythematous, Estrogen, Seizurs, Photophobia, Luupus Nephritis.

Page No: 116-118 | Full Text

 

Original Research Article

THE ANTI-HYPERTENSIVE EFFECTS OF HIGH DOSE TELMISARTAN AND LOW DOSE COMBINATION THERAPY TELMISARTAN + AMLODIPINE IN PATIENTS WITH HYPERTENSION, AT GGH, BY DEPARTMENT OF PHARMACOLOGY, KURNOOL MEDICAL COLLEGE, KURNOOL, ANDHRA PRADESH - A PROSPECTIVE STUDY”

http://dx.doi.org/10.5530/ijmedph.2024.2.24

Haritha. Pulla Reddy, Rajanikanth. M, Anush. K, Lakshmi Kameswari.V

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Hypertension is defined as a systolic blood pressure (SBP) of 140 mm Hg or more, or a diastolic blood pressure (DBP) of 90 mm Hg or more. Globally, an estimated 26% of the world’s population (972 million people) has hypertension, and the prevalence is expected to increase to 29% by 2025, driven largely by increase in economically developing nations. Hypertension affects one in four individuals worldwide. ARBs, CCBs are first line of therapy of hypertension and has out shifted the use of ACEIs. Telmisartan is the preferable ARB, Amlodipine a third generation CCB are commonly prescribed for hypertension in INDIA. Telmisartan has a very high lipophilicity and high volume of distribution which offers advantage of good tissue penetration over other sartans. Amlodipine a DHPs of CCBs is prescribed because of less negative inotropic and high vascular selectivity. The present study comprises of 60 patients (both men and women) of 18 and above age, who are suffering from idiopathic hypertension to know the efficacy of low dose combination therapy of Telmisartan(40mg) with Amlodipine (5mg) against high dose monotherapy of Telmisartan(80mg). In present study, a low dose combination therapy of Telmisartan 40mg + Amlodipine 5mg has demonstrated significantly greater BP reduction in both SBP and DBP compared to high dose monotherapy with Telmisartan 80mg.The combination therapy with Telmisartan 40mg + Amlodipine 5mg is well tolerated with a safety profile similar to the monotherapy with Telmisartan 80mg. Keywords: CCB- Calcium channel blocker, ARB- Angiotensin receptor blocker, SBP-Systolic blood pressure, DBP- Diastolic blood pressure.

Page No: 119-124 | Full Text

 

Original Research Article

ANALYZING DIFFERENT METHODS OF FOOT DEFECT RECONSTRUCTION AND THEIR OUTCOMES: A PROSPECTIVE STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.25

Syeda Asfia Tamkeen, Kommu Vijay Babu, N. Nagaprasad, Lakshmi Palukuri

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Background: Foot defects requiring reconstructive surgery pose significant challenges in plastic and reconstructive surgery. Understanding the demographic characteristics, clinical presentations, surgical interventions, and outcomes of foot reconstruction is essential for optimizing patient care. This prospective observational study aimed to analyze the demographics, clinical presentations, surgical interventions, and outcomes of elective foot reconstruction surgeries. Materials and Methods: Over a 24-month period, 50 cases undergoing elective foot reconstructive surgery were studied. Demographic data, including age, sex, etiology, and comorbidities, were recorded. Clinical characteristics such as foot involvement, defect size, structures exposed, associated fractures, and vascular status were assessed. Surgical interventions and complications, including type of reconstruction and post-operative outcomes, were documented. Functional outcomes and patient satisfaction were evaluated during follow-up. Results: The majority of patients (72%) were aged 18-40 years, with males comprising 84% of the study population. Trauma was the leading etiology (88%) of foot defects, and 22% presented with associated comorbidities. Most defects were right-sided (68%) and ranged from 5-10 cm in size (70%). Bones and tendons were commonly exposed (48%), and 60% of patients had associated fractures. Lateral supramalleolar flap and RSA flap were the most common reconstruction procedures (both 26%). Flap necrosis and donor site morbidity affected 8% and 24% of patients, respectively. Despite challenges, 94% of patients reported satisfaction with the outcome of their reconstruction. Conclusion: Elective foot reconstruction surgeries present complex clinical scenarios. This study provides insights into the demographics, clinical characteristics, surgical interventions, and outcomes of foot reconstruction, aiding in optimizing patient management and improving surgical outcomes. Keywords: Foot reconstruction, plastic surgery, reconstructive surgery, clinical characteristics, surgical interventions, outcomes.

Page No: 125-130 | Full Text

 

Original Research Article

EXPLORING HEMOGLOBIN DISORDERS IN REPRODUCTIVE-AGE FEMALES: A PROSPECTIVE OBSERVATIONAL STUDY IN RURAL HARYANA, INDIA

http://dx.doi.org/10.5530/ijmedph.2024.2.26

Navtej Kumar, Neha Batra, Surbhi Rajauria, Charu Batra Atreja, Agam Hans, Maninder Kaur

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Background: Hemoglobinopathies, a diverse group of genetic disorders affecting hemoglobin synthesis or structure, pose substantial public health challenges worldwide. Understanding their prevalence and spectrum, especially among reproductive-age females, is crucial for planning effective prevention and treatment strategies. Aim: This prospective observational study aimed to investigate the frequency of hemoglobinopathies among reproductive-age females in a rural tertiary care centre in Haryana using high-performance liquid chromatography (HPLC). Materials and Methods: Over the course of one year, 149 females aged 15 to 45 years were included in the study. Blood samples were collected and analysed using HPLC to identify haemoglobin abnormalities. Results: Haemoglobin HPLC analysis revealed haemoglobinopathies in 14.1% of cases, with β-thalassemia trait being the most prevalent (11.4%). Other hemoglobinopathies identified included HbD Punjab trait and HbE trait. Haematological indices provided insights into different parameters across various hemoglobinopathies. Conclusion: Hemoglobinopathies represent a significant healthcare challenge in India, particularly among women of reproductive age. This study emphasizes the importance of screening for carriers using haemoglobin HPLC, as it facilitates the provision of tailored counselling and management strategies to alleviate the impact of these disorders. Keywords: Haemoglobinopathies, reproductive-age group, blood disorder, Anaemia, haemoglobin.

Page No: 131-134 | Full Text

 

Original Research Article

PROSPECTIVE CLINICAL STUDY ON THE REPAIR OF UNCOMPLICATED ISOLATED EXTENSOR TENDON INJURIES OF THE HAND IN A TERTIARY CARE CENTER IN HYDERABAD

http://dx.doi.org/10.5530/ijmedph.2024.2.27

Kommu Vijay Babu, Syeda Asfia Tamkeen, Raja Kiran Kumar Goud Ireni, Palli Shirin

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Background: Extensor tendon injuries are common and can significantly impact hand function. The treatment and management of these injuries vary widely, influencing the functional outcomes. To evaluate the efficacy of different management protocols (early active mobilization vs. immobilization) in the repair of uncomplicated isolated extensor tendon injuries and to assess the outcomes based on the Total Active Range of Motion (TAM). Materials and Methods: This prospective analytical study included all cases of extensor tendon injuries treated in the Department of Plastic and Reconstructive Surgery. Patients were assigned to either an early active mobilization/physiotherapy protocol or to immobilization due to non-compliance based on specific criteria. The primary outcome measure was the improvement in TAM as suggested by the American Society for Surgery of the Hand. Results: A total of 66 patients with 100 tendon injuries were included. The majority were males (87.8%), with the most affected age group being 10-30 years (77%). The index finger was the most frequently injured. Outcomes showed 70% of tendons had good to excellent recovery. Early active mobilization yielded fewer complications and better functional outcomes compared to immobilization. Conclusion: Early active mobilization significantly enhances recovery in extensor tendon injuries of the hand. This protocol also demonstrated lower complication rates, making it a preferable treatment strategy in compliant patients. Keywords: Extensor tendon injuries, early active mobilization, immobilization, hand surgery, Total Active Range of Motion (TAM), functional outcomes.

Page No: 135-141 | Full Text

 

Original Research Article

FEASIBILITY OF PRIMARY CARE NURSE BASED GENETIC INFORMATION AND COUNSELLING SERVICE DELIVERY FOR MAINSTREAMING IN OVARIAN CANCER PATIENTS- A MIXED METHOD STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.28

Priyanka Singh

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Background: Genetic testing for Breast Cancer (BRCA) gene 1 and 2 mutations in epithelial ovarian cancers is recommended to guide prognosis, adjuvant treatment and prevention of second malignancies in the patient and in the carrier family members or relatives. Prevalence of BRCA and other cancer- causing mutations is not known in most regions in India and is inadequately explored. Main-streaming genetic testing has the potential to increase uptake of testing in patients and identify at-risk carrier population in whom primordial or primary prevention of genetic cancers can be implemented with good outcomes. Materials and Methods: A mixed method study was conducted with aim to explore feasibility of a primary care nurse based genetic counselling modality for ovarian cancer patients, along with exploration of factors affecting its uptake, using a structured objective survey questionnaire followed by key informant interviews to develop qualitative questionnaire for further phase of the study. Results: The uptake of genetic testing among patients was good and among healthy relatives was negligible. The affecting factors were lack of awareness and economic. The qualitative study interview explored reasons for low uptake of tests, satisfaction with the counselling and impact of test results on patients. Conclusion: The pretest counselling was effective and post-test counselling necessitated counselling by specialist oncologist. The uptake of genetic testing was affected by level of awareness and costs. Keywords: Mainstreaming genetic testing, Nurse led counselling, Ovarian cancer.

Page No: 142-146 | Full Text

 

Original Research Article

A STUDY ON SURGICAL OUTCOME OF PROXIMAL HUMERUS FRACTURE TREATED WITH PROXIMAL HUMERAL NAILING

http://dx.doi.org/10.5530/ijmedph.2024.2.29

Kumaresapathy.S, Praveen.B, Karthikeyan. E. S, Manikandan.R

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Background: The proximal humerus is the third most common fractured bone in the body, making up about 4%-5% of all fractures. Incidence occurs mostly after distal radius fractures and hip fractures. Fractures of the proximal humerus are more common among the elderly. Studying the outcomes of proximal humeral nailing fixation for two- and three-part proximal humeral fractures was the primary focus of this prospective observational study. This study was conducted to assess the clinical, radiological and functional outcome of treating Neer 2, 3-part proximal humerus fracture using intramedullary proximal humerus nailing and to know the advantages, disadvantages and complications of the procedure. Materials and Methods: A prospective study was conducted in K A P V govt Medical College& MGMGH, Trichy. This study included the patients with fracture of proximal humerus requiring surgical interventions, after taking their consent, were analyzed clinically and radiologically. All the patients selected for the study were evaluated as per the history & mode of injury, necessary clinical and laboratory investigations. The pre-operative and immediate post-operative X-ray were evaluated. The patients were evaluated clinically and radiologically in their subsequent follow-up every 6 weeks till fracture union and at 1 year after surgery. Results: The time for union (weeks) was 11 to 14 weeks in86.66% of the participants. Most of the patients had follow-up till one year. The mean post op NEER score 75.17 ± 5.85 at 6 weeks, it was 79.63 ± 5.3 at 3 months, it was 83.23 ± 5.28 at 6 months, it was 88.5 ± 5.48 at final score.36.67% and 63.33% of the participants had NEER 2 and 3part type of fracture injury. Among the study population with post-op complication, 10.00% of them had varus malunion, 6.67% of them had rotator cuff injury, 3.33% of them had glenohumeral protrusion. We found that 63.33% of them had excellent outcomes, 26.67% of them had satisfactory outcomes, 10.00% of them had unsatisfactory outcomes. Conclusion: We discovered that individuals with both two and three-part fractures exhibit successful fracture union. Post-operative NEER score was improved with the patients treated. We found that there was a good outcome with a smaller number of complications found in the treatment of proximal humeral nailing. Keywords: Proximal Humerus, NEER scores, Post-operative, Proximal Humerus Nailing.

Page No: 147-151 | Full Text

 

Original Research Article

A CLINICAL STUDYOF LATERAL NECK SWELLINGS IN ADULTS IN TERTIARY CARE HOSPITAL

http://dx.doi.org/10.5530/ijmedph.2024.2.30

Rizwaan N, Sathish Kumar K N, Suvaries Princy Maria Salvodar

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Background: Lateral neck swellings in ENT have various causes, commonly found in the anterior triangle of the neck. Accurate diagnosis through imaging, FNAC, and biopsy is crucial for appropriate treatment, ranging from conservative management to surgery. Understanding incidence, etiology, pathology, and clinical behaviour is important for effective management and follow- up. Materials and Methods: Institutional Ethical committee approval was obtained and informed consent was taken from the study subjects. Patients with lateral neck swellings underwent clinical examination and FNAC, followed by further investigations based on FNAC reports. Lymph node biopsies were taken for histopathological examination. Management was based on the final diagnosis, and patients were followed up for six months. Results were analyzed and tabulated. Results: In our study of 96 patients, lateral neck masses were most common in individuals aged 46-59, with an equal male-to-female ratio. The majority of cases (82.29%) were from low socioeconomic status. Metastasis in cervical lymph nodes was the most frequent cause of lateral neck swellings, primarily in males aged over 45, and tubercular lymphadenitis was the second most common cause in females aged 18-30. The clinical diagnosis had high sensitivity (87.18%) and specificity (92.98%) for detecting malignant lesions, and these values increased when the histopathological examination was used as the gold standard. Conclusion: To evaluate and manage lateral neck swellings, a multidisciplinary approach is necessary, including medical history, clinical examination, imaging, and pathological investigations like FNAC and HPE. Prompt and accurate diagnosis is critical to prevent morbidity and mortality, and management depends on the underlying cause. Effective management requires close communication between the clinician and the pathologist. Keywords: Cervical Lymphadenopathy; non-thyroid neck swellings; Benign; Malignant; Fine-needle aspiration cytology; Histopathological examination; Neck metastasis; Tuberculosis; Lymphoma.

Page No: 152-158 | Full Text

 

Case Series

NEURAL TUBE DEFECTS: IS THERE A NEED TO IMPLEMENT THE FORTIFICATION OF STAPLE FOOD WITH FOLIC ACID? A CASE SERIES AT TERTIARY CARE CENTER

http://dx.doi.org/10.5530/ijmedph.2024.2.31

Mahima Gawalkar, Surekha. S. M, B. H. Narayani, Vinaya G

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Background: Neural tube defects, serious birth defects affecting the brain & spine, are a major, preventable public health burden. Aim and Objectives: 1) Periconceptional folic acid intake in any means to prevent NTDs in unplanned pregnancy. 2) To understand the need to implement the fortification of staple food with folic acid. Material and Methods: Total of 10 cases (from March 2022 to March 2023 in KIMS, Koppal) with neural tube defects. Results: Various presentations with neural tube defects were seen in this case series. Unplanned pregnancies and unawareness regarding benefits of folic acid supplementation leading to higher incidence of neural tube defects. Conclusion: New efforts that is implementation of fortification of staple food with folic acid along with practicing primary prevention such as dietary folate intake, periconceptional folic acid intake are needed to implement a combined strategy to reduce the incidence of neural tube defects. Keywords: Neural Tube Defects, Folic Acid, Fortification, Food.

Page No: 159-162 | Full Text

 

Original Research Article

ANALYSIS OF ROLE OF SERUM LIPID PROFILE AS RISK FACTOR FOR DEVELOPMENT OF ISCHEMIC STROKE AT A TERTIARY CARE HOSPITAL

http://dx.doi.org/10.5530/ijmedph.2024.2.32

Nihar Pankaj Upadhyay, Jashwant L Menat, Pyarpinkesh N Rathva, Devika S Vasava

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Background: Stroke, a cerebrovascular accident, is prevalent across patient populations and can be a significant cause of morbidity and mortality. Ischemic occlusions contribute to around 85% of casualties in stroke patients, with the remainder due to intracerebral bleeding. Hyperlipidemia is a major contributor to coronary heart disease, but its relationship to stroke is complicated. Hence; the present study was conducted for assessing the role of serum lipid profile as risk factor for development of ischemic stroke. Materials & Methods: A total of 100 patients with ischemic stroke and 100 controls who came for routine medical check-up were enrolled. Complete demographic and clinical details of all the patients was obtained. The diagnosis of stroke was confirmed by taking CT scan of brain. Lipid profile was taken following a 12 hour fasting on the next day of admission. Serum total cholesterol less than200mg/dl, LDL cholesterol<100 mg/dl, triglyceride less than150mg/dl, and HDL more than 40 mg/dl was taken as normal. Data was analyzed using SPSS software. Results: Mean age of the stroke patients and controls was 53.9 years and 55.1 years respectively. Majority proportion of patients of both the study group and control group were males. Significant difference was obtained while comparing TC, LDL-C and HDL-C among the stroke patients and controls. While comparing the dyslipidemia, is was seen that ischemic stroke group had significantly higher proportion of patients with dyslipidemia in comparison to controls. Conclusion: Lipids give significant contribution to stroke risk and that lipid profile assessment must be taken into account in estimating the individual risk of stroke. Key words: Lipid, Ischemic, Stroke.

Page No: 163-165 | Full Text

 

Original Research Article

ROLE OF HYSTEROSCOPY IN EVALUATION OF UTERINE CAVITY ABNORMALITIES IN PATIENTS OF INFERTILITY: A COMPARATIVE STUDY WITH SONOGRAPHY

http://dx.doi.org/10.5530/ijmedph.2024.2.33

Jyoti Yadav, Mahjabin, Shruti Manchanda, Vikram Samadhan Lokhande

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Background and Objectives: Infertility is a significant concern affecting many couples of reproductive age. This condition arises due to a myriad of factors, and relying solely on pelvic examinations may not adequately detect all infertility-related abnormalities. Therefore, there is a need for additional diagnostic and therapeutic investigations. Transvaginal Ultrasound (TVS) has emerged as a crucial initial step in assessing uterine abnormalities, although numerous studies have established hysteroscopy as the gold standard. The aim of this study was to compare the findings of transvaginal ultrasound with hysteroscopy in evaluating uterine cavity and its abnormalities in infertility patients prior to undergoing in vitro fertilization (IVF). Methods: This prospective, hospital-based study was carried out at a tertiary healthcare facility in India. It involved a cohort of 123 patients experiencing infertility, who were assessed using transvaginal sonography (TVS) followed by hysteroscopy. Data from these evaluations were documented and subjected to statistical analysis using SPSS 20 with significance level set at 5%. Results: The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of TVS were found to be 82.50%, 73.00%, 91.80%, 66.50%, and 80.50%, respectively. In comparison, hysteroscopy demonstrated sensitivity, specificity, PPV, NPV, and accuracy of 97.50%, 97.90%, 99.50%, 86.50%, and 92.50%, respectively. When both hysteroscopy and TVS were combined for intrauterine pathology evaluation, the values significantly increased to 98.80%, 99.80%, 99.80%, 98.00%, and 95.50%, respectively. Conclusion: Transvaginal ultrasound serves as a sensitive, cost-effective, and non-invasive tool for detecting pelvic pathologies in infertility patients. However, hysteroscopy emerges as a more sensitive method for uterine evaluation. Combining both techniques enhances diagnostic yield in terms of sensitivity and specificity, thus improving overall diagnostic accuracy. Key Words: Ultrasound, Infertility, Hysteroscopy, Uterus

Page No: 166-169 | Full Text

 

Original Research Article

PULMONARY FUNCTION TEST AMONG OBESE AND NON-OBESE ADULT POPULATION OF KERALA: A COMPARATIVE CROSS-SECTIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.34

Jyothi Damodar

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Background: The objective of this study was to assess the impact of obesity on pulmonary functions, such as FEV1/FVC ratio, PEFR, and MVV, in adults aged 26 to 55, comparing those with abdominal obesity against non-obese individuals. Materials and Methods: Over one year, the present cross-sectional study was carried out at the Academy of Medical Sciences in Pariyaram. The study comprised 200 non-obese patients and 200 subjects with abdominal obesity, including both males and females. The study sample comprised individuals between the ages of 26 and 55. Spirometry measurements were conducted on all subjects while they were seated, following the procedures advised by the American Thoracic Society. A proficient technician conducted a spirometry examination in the morning. The pulmonary functions that were evaluated include the FEV1/FVC ratio, PEFR, and MVV. The BMI was determined by recording the weight and height. The statistical analysis was conducted using IBM SPSS for Windows (Version 26.0). An Unpaired t-test was employed to evaluate the PFT of those classified as non-obese and those with abdominal non-obesity. A p-value of less than 0.05 was deemed statistically significant. Results: The participants were categorized into three distinct age groupings, namely 26-35 years, 36-45 years, and 46-55 years. BMI cut-off values of more than 25 kg/m2 were used to divide the participants into two groups: those with abdominal obesity and non-obese. In the abdominal obesity group, 49.5% of the 200 participants were men and 50.5% were women. In the group of non-obese individuals, there was an equal distribution of males and females. The study sample revealed a statistically significant difference in the average FEV1/FVC ratio between individuals with abdominal obesity and non-obese across all age categories. The study observed a decline in mean PEFR levels as individuals aged in both groups. The participants with abdominal obesity and non-obese showed a statistically significant difference in mean PEFR values (p < 0.01). The abdominal obesity group aged 46-55 years exhibited an MVV of 69.58±12.56 L/min. The statistical analysis revealed a significant difference in the average MVV values between individuals with abdominal obesity and non-obese in the age ranges of 26-35, 36-45, and 46-55 years. Conclusion: The results of the study indicated that there was a consistent decrease in lung function measures as individuals aged in both groups. The abdominal obesity group exhibited a notable decrease in FEV1/FVC, PEFR, and MVV when compared to the non-obese group. Keywords: Abdominal obesity, Body mass index, Maximum voluntary ventilation, Peak Expiratory Flow Rates, Pulmonary function tests.

Page No: 170-173 | Full Text

 

Original Research Article

ASSESSMENT OF BIOMEDICAL WASTE MANAGEMENT AWARENESS, PRACTICES, AND NEEDLE STICK INJURIES AMONG HEALTHCARE WORKERS IN GOVERNMENT HOSPITALS OF JABALPUR, MADHYA PRADESH

http://dx.doi.org/10.5530/ijmedph.2024.2.35

Prashant Verma, Aditya Thakur, Aryasree L, Rajesh Tiwari

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Background: Inadequate biomedical waste management can directly impact health. As per ministry reports, India produces over 62 million tons of waste annually, of which 15% is biomedical waste. Objectives: To assess the awareness of healthcare staff regarding biomedical waste management practices in the selected government hospitals of Madhya Pradesh. To determine the current practices of biomedical waste management in the hospitals. To assess the needle stick injury rate. Materials and Methods: Hospital-based cross-sectional study. The study conducted over a period of 2 months Feb 2024 to March 2024 across two randomly selected government hospitals in Madhya Pradesh. Healthcare staff (doctors, nurses, lab technicians and sanitary staff) involved in handling of biomedical waste were included. Simple random sampling was used to select the study participants in each hospital after allocating proportionate samples for the different staff categories. Data was collected using a pre-tested, semi-structured questionnaire. Results: The assessment found that 52% had moderate knowledge of BMW management while 8% had poor knowledge. Most reported following safe practices with over 80% doing things like 92% wearing gloves and 88% separating BMW. However, sometimes only 63% followed correct hospital waste disposal. 10% reported a needlestick injury in the last year, with individual carelessness and poor needle disposal being the top causes each at 40%. Conclusion: While over half demonstrated moderate knowledge of appropriate BMW procedures, there remains room for improvement as 8% exhibited poor knowledge. Keywords: Biomedical waste; Awareness; Practices; Needlestick injuries; Healthcare workers.

Page No: 174-179 | Full Text

 

Original Research Article

TO STUDY THE SLEEPING PATTERN AND ITS EFFECT ON STUDENTS PREPARING FOR MEDICAL ENTRANCE IN INDORE DISTRICT

http://dx.doi.org/10.5530/ijmedph.2024.2.36

Prachi Jasuja, Veena Yesikar, Shailesh Rai, Divya Swami

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Background: Sleep is a physiological process essential to life. Its quality is strongly related to psychological and physical health and other measures of well-being. Sleep also allows the brain to better process new experiences and knowledge which increases understanding and retention. Aims and Objectives: To find out the percentage of altered sleeping pattern among students preparing for medical entrance. Materials and Methods: Data was collected using a Pre-Designed Semi Structured Questionnaire based on The PSQI (Pittsburgh’s Sleep Quality Index) consists of 19 self-rated question and five question rated by the bed partner or roommate. Data was entered in Microsoft excel spread sheet and analysed using Epi-data software. Chi square test was applied. Results: It was found that 55% of study population is having a sleep quality index score >5 i.e. their sleep quality is poor. There were 43% students who sleep for 6-8 hours, 27.5% who sleep for 4-6 hours, 9% sleep for 7-9 hours and 2.5% sleep >10 hours a day. Conclusion: The prevalence and effect of insufficient sleep is high among the aspirants preparing for medical entrance exams due to increasing competition, due to which they keep on delaying their urge to sleep which in turn is affecting their normal sleep-wake cycle. Also, the students are facing many sleep movement disorders at a very young age. Keywords: Sleeping pattern, Medical entrance, Students, Sleep-cycle.

Page No: 180-183 | Full Text

 

Original Research Article

THE IMPACT OF AGE AND GENDER ON THE MORPHOLOGY OF THE HUMAN SKULL: A CROSS-SECTIONAL ANALYSIS

http://dx.doi.org/10.5530/ijmedph.2024.2.37

Lakkireddy Vasanthi, Bala Maheswari K, GN Charitha, Vemavarapu Mahesh

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Background: Understanding the variations in human skull morphology due to age and gender is crucial for applications in forensic anthropology, clinical medicine, and related fields.This study aims to assess the impact of age and gender on various skull morphological parameters across a sample of 50 individuals. Material and Methods: A cross-sectional analysis was performed using high-resolution imaging to measure cranial volume, facial angle, jawbone structure, orbital size, skull length, zygomatic width, and mandibular angle. The sample was balanced for gender with 25 males and 25 females ranging in age from newborns to the elderly (over 60 years). Results: Age-related changes were significant, with cranial volume peaking during late adolescence and decreasing slightly in older age. The facial angle and other parameters expanded or increased until reaching stability in adulthood. Notable gender differences were also observed, where males generally exhibited larger values in nearly all parameters measured. These findings are comprehensively detailed in Tables 1 and 2. Conclusion: The study highlighted significant morphological changes associated with both age and gender. Early life featured rapid growth in most parameters, which stabilized in adulthood and slightly declined in the elderly. Males displayed consistently larger skull dimensions than females. These distinctions are essential for enhancing accuracy in forensic applications and improving anthropological understanding of human skull development. Keywords: Skull morphology, age-related changes, gender differences, cranial volume, forensic anthropology, zygomatic width, mandibular angle.

Page No: 184-187 | Full Text

 

Original Research Article

A STUDY ON EVALUATION OF EFFECTIVENESS OF PRE-PERITONEAL MESH REPAIR FOR BILATERAL AND RECURRENT INGUINAL HERNIA

http://dx.doi.org/10.5530/ijmedph.2024.2.38

Nadigadda Mohammed Shukur

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Background: Inguinal hernia repairs are the one of most common type of surgeries performed worldwide. Surgical treatment of the defect is the only permanent solution. This study was done to evaluate the effectiveness of using pre-peritoneal mesh to repair the defects in patients with bilateral and recurrent inguinal hernias. Materials and methods: this prospective study was conducted including 100 patients presenting with bilateral inguinal hernias or recurrent inguinal hernia to the OPD of Department of surgery of KIMS, Narketpally over a period of 1 year. Results: 98% of the patients were males and majority of the patients were in their middle age group. Most of the patients had groin swelling as the most common presenting complaint. Most of the patients were in occupations involving heavy strength work. Smoking and lifting of heavy weights are the most commonly observed risk factors in present study. Majority of the patients had their procedures finished within 30-45 min. most of the patients had mild post-operative pain and were discharged within 2 days of the procedure. Conclusion: Open pre-peritoneal mesh repair is a cost-effective procedure with few post-operative complications, less requirement of anesthesia and short duration of surgery, early discharge from the hospital. Keywords: Hernia, pre-peritoneal mesh repair, open approach, bilateral, recurrent hernia.

Page No: 184-190 | Full Text

 

Original Research Article

ROLE OF SERUM UROMODULIN AS A BIOMARKER OF DECLINE IN RENAL FUNCTION IN CHRONIC KIDNEY DISEASE

http://dx.doi.org/10.5530/ijmedph.2024.2.39

Soma Ananth, M.Sreedhar Sharma, PL.Venkata Pakki Reddy, Manoj Umare

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Background: Uromodulin (Tamm–Horsfall protein), the most common protein in normal urine present in a bundant quantity, is increasingly considered as a potential biomarker relevant to kidney function and tubular reserve, chronic kidney disease and hypertension. A reduced number of tubular cells, is paralleled by reduced urinary and serum concentrations of uromodulin. Therefore, uromodulin might represent a promising biomarker for CKD. Aim: To evaluate the use of serum uromodulin as a biomarker in chronic kidney disease patients. Material and Methods: In an observational study, on 100 subjects with 50 normal healthy and 50 with CKD 1 – 5 stages patients attending Nephrology department in a tertiary care hospital for two years were enrolled. Lipid profile, Serum calcium, proteins, creatinine and serum Uromodulin along with e GFR was investigated. Data was analyzed using SPSS 16 and by using t test, ANOVA and correlation coefficients. Results: Mean age of the study participants was 47.47 ± 10.66 years. And 71% were male. On comparison between cases and controls, Serum Uromodulin, calcium, HDL was lower and other lab findings were significantly more in Cases than in controls. Serum Uromodulin was significantly decreased with severity of CKD. Conclusion: A comparative analysis of serum uromodulin with e GFR shows that eGFR is positively correlated with uromodulin. Lower serum uromodulin reflects a decline in kidney function. Thus serum uromodulin is a helpful marker in diagnosis of CKD at a nearly stage. The estimation of serum uromodulin level may aid in early diagnosis of kidney dysfunction and also in predicting the progression of disease. Keywords: Biomarker, Chronic Kidney disease, Renal function, Serum Uromodulin.

Page No: 191-195 | Full Text

 

Original Research Article

PATTERNS OF ANAESTHETIC DRUG USAGE IN SUSPECTED CASES OF PEDIATRIC ABUSE: A FORENSIC AND CLINICAL OBSERVATIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.40

K. Pramod Kumar, R. Balram, Suvarna B., Prashanth Kumar Patnaik

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Background: Suspected cases of pediatric abuse often involve the administration of anaesthetic drugs, posing significant risks to the well-being of affected children. Understanding the patterns and clinical implications of anaesthetic drug usage in such cases is crucial for effective detection and intervention. This study aimed to analyze the prevalence, types, dosage patterns, clinical presentations, and forensic implications of anaesthetic drug usage in suspected cases of pediatric abuse. Material and Methods: A comprehensive observational study was conducted, involving the analysis of 100 suspected cases of pediatric abuse. Anaesthetic drug usage was meticulously examined, and data were collected regarding the types of drugs administered, dosage patterns, clinical presentations, and forensic implications. Results: Among the suspected cases, 65% exhibited evidence of anaesthetic drug usage, with Propofol being the most prevalent (40%), followed by Ketamine (30%) and Benzodiazepines (20%). High dosage administration was observed in 25% of cases, while 15% involved low dosage administration. Respiratory depression (60%) and CNS depression (45%) were the most common clinical presentations associated with anaesthetic drug usage. Additionally, 45% of cases involved the simultaneous administration of multiple anaesthetic drugs. Forensically, the identification of specific anaesthetic drugs and their dosage patterns served as crucial evidence in cases of suspected pediatric abuse. Conclusion: Anaesthetic drug usage is prevalent in suspected cases of pediatric abuse, with significant clinical and forensic implications. Our findings underscore the importance of vigilance among healthcare providers and the implementation of robust child protection measures to detect and intervene in cases involving anaesthetic drugs. Enhanced awareness and understanding of these patterns are essential for safeguarding the well-being of vulnerable children. Keywords: Pediatric abuse, anaesthetic drugs, prevalence, dosage patterns, clinical presentations, forensic implications.

Page No: 196-199 | Full Text

 

Original Research Article

EFFECTS OF ANESTHETIC TECHNIQUES ON PEDIATRIC OUTCOMES: AN OBSERVATIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.41

R. Balram, K. Pramod Kumar, Shilpa Dakoji, Prashanth Kumar Patnaik

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Background: The physiological and psychological distinctions between children and adults pose challenges for pediatric anesthesia. The backbone of pediatric surgeries has always been general anesthesia; however, toxic consequences, especially in younger children, have prompted a reevaluation of anesthetic procedures. This concern has led to research into alternatives such as regional and neuraxial procedures. The purpose of the study is to investigate how various anaesthetic techniques affect paediatric outcomes. Material and Methods: This is prospective observational research with 120 paediatric patients having surgery that is elective. Patients who underwent general, regional, neuraxial, anaesthetic procedures were divided into 3 groups. Data on demographics, intraoperative parameters, and postoperative results gathered and analysed. Results: A total of 120 study participants were chosen for the study in order to investigate the effects of different anaesthetic techniques. Patients in Group B (regional anaesthesia) experienced 25% less postoperative pain than those in Group A (general anaesthesia) (p < 0.05). On the other hand, Group A saw a 20% greater incidence of emerging delirium than Group B (p < 0.05). Group C (neuraxial procedures) and Group A did not show statistically significant differences in postoperative pain evaluations. Instead, the scores were determined to be similar. Conclusion: Our study unfolds the importance of assessing different anaesthetic procedures in paediatric surgery. While general anaesthesia was associated with a higher incidence of emerging delirium, regional anaesthesia demonstrated improved pain control. Postoperative pain results from neuraxial surgeries were similar to those from general anaesthesia. In order to maximize patient care and outcomes, our data highlight the significance of personalized anaesthetic techniques in paediatric surgery. Keywords: Pediatric anesthesia, Anesthetic techniques, Customized anesthesia, Pediatric surgery, Anaesthesia safety.

Page No: 200-203 | Full Text

 

Original Research Article

A STUDY ON ANALYSIS OF OBSTETRIC REFERRALS TO A TERTIARY CARE HOSPITAL

http://dx.doi.org/10.5530/ijmedph.2024.2.42

Pagadala Sri Venkateswara Mohana, T. Prathibha Sravanthi

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Background: Adequate facilities for deliveries and for managing high risk pregnancy cases may not be available at all hospitals along with round the clock working staff. This study was done to identify the types of cases being referred and to study reasons for referral to tertiary care setup for management. Material and Methods: This prospective study was conducted over a period of 3 months in the Department of Obstetrics and Gynaecology, Government Maternity Hospital, Tirupati and included a total of 417 cases who were referred to this tertiary care center for further management. The following variables were analysed like age, birth order, referring facility, reasons for referral. Results: Most of the patients were from rural background. 20-40 years aged women were predominant. Primigravida women were mostly being referred. The maximum number of cases were referred from the nearby area hospitals. Previous history of cesarean section and premature rupture of membranes were the most common reasons for referral. Conclusion: Strengthening of the health care facilities and proper training of the staff so that they can decide when to refer and whom to refer can reduce the maternal mortality and morbidity significantly. Keywords: Pregnancy, Primary health care, Referral system, Tertiary hospital.

Page No: 204-207 | Full Text

 

Original Research Article

A STUDY ON COMPARISION OF PALONOSETRON WITH ONDANSETRON FOR PREVENTION OF NAUSEA AND VOMITING DURING POSTOPERATIVE PERIOD IN PATIENTS UNDERGOING ENT SURGERIES

http://dx.doi.org/10.5530/ijmedph.2024.2.43

Abhidhya Reddy, Sheetal Meena, Vaishnavi Ambatipudi, Vaibhav Kumar Gupta, Sachidanand R S

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Background: Incidence of postoperative nausea and vomiting (PONV) in susceptible patients can be unacceptably high (70-80% reported incidence). This study was designed to evaluate the effect of palonosetron and ondansetron in preventing PONV in high-risk patients undergoing ENT surgeries conducted under general anaesthesia. Aim: The objective of the present studyis to compare the intravenous Palonosetron with intravenous Ondansetron for prevention of nausea and vomiting during postoperative period in patients undergoing ENT Surgeries underGeneral Anaesthesia. Material and Methods: This was a randomized double blindclinical study conducted on 60 ASA Grade I&II patients scheduled for ENT Surgeries under General Anaesthesia and were randomlydivided into two groups, Group I and Group II, each consisting of30 patients. Group I received 4 mg of Ondansetron I.V and GroupII received 1.5 mcg/kg of Palonosetron I.V, 30 minutes before theinduction of anaesthesia. The incidences of PONV were recorded within the first 72 hours after surgery at intervals of: 0-12 hours,12-24 hours and 24-72 hours. Episodes of PONV were identifiedby spontaneous complaints by the patients, by direct questioningand by Nausea Scale (Visual Analogue Scale) 0 -10. Results: There were no differences in the demographic databetween the two study groups. The incidence of PONV was significantly less in the palonosetrongroup (5.55%) as compared to the ondansetron group (43.33%), with a lesser need for rescue antiemetic in the palonosetron group (10% vs. 53%). Both the study groups did not have significantadverse effects reflecting that both the drugs were well-tolerated. Conclusion: In conclusion, we have found that Palonosetron at adose of 1.5mcg/Kg IV is safe and well-tolerated and proved more effective than Ondansetron 4 mg IV in the prevention of PONV. Keywords: PONV, Palonosetron, Ondansetron, ENT Surgery.

Page No: 208-212 | Full Text

 

Original Research Article

A CROSS-SECTIONAL STUDY ON POSTOPERATIVE NAUSEA AND VOMITING ACROSS DIFFERENT TYPES OF ANESTHESIA

http://dx.doi.org/10.5530/ijmedph.2024.2.44

Ashok Kumar Kothapalli, Katla Vijay Kumar, Suvarna B., Vaddadhi Sindhuri, Shilpa Dakoji

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Background: Postoperative nausea and vomiting (PONV) is a common complication following surgery, with varying incidence across different types of anesthesia. This cross-sectional study evaluates the incidence, severity, duration, and management of PONV in patients undergoing surgery under general, regional, or local anesthesia with sedation. Material and Methods: A total of 100 patients undergoing various surgical procedures were grouped based on the anesthesia received: general anesthesia (n=50), regional anesthesia (n=30), and local anesthesia with sedation (n=20). Incidence, severity (mild, moderate, or severe), duration, and antiemetic management of PONV were assessed. Descriptive statistics were used to analyze the data. Results: PONV incidence was highest in the general anesthesia group, with 28 out of 50 patients (56%) experiencing PONV, compared to 9 out of 30 (30%) under regional anesthesia and 4 out of 20 (20%) under local anesthesia with sedation. The severity of PONV varied, with 18 cases of mild nausea, 7 moderate, and 3 severe vomiting reported in the general anesthesia group. Regional anesthesia yielded 6 mild and 3 moderate cases, while local anesthesia with sedation reported only 4 mild cases. The duration of PONV averaged 6 hours under general anesthesia (range: 2-12 hours), 4 hours under regional anesthesia (range: 1-7 hours), and 2 hours under local anesthesia (range: 1-4 hours). Antiemetics were administered to 34% of patients experiencing PONV under general anesthesia, 22% under regional anesthesia, and none under local anesthesia. Conclusion: General anesthesia is associated with the highest incidence and severity of PONV. Choosing appropriate anesthesia methods and managing risk factors is critical to reducing PONV. Keywords: Postoperative nausea and vomiting, PONV, anesthesia, general anesthesia, regional anesthesia, local anesthesia with sedation.

Page No: 213-217 | Full Text

 

Original Research Article

KNOWLEDGE AND PRACTICE OF PASSIVE SMOKING: A PARENTS’ PERSPECTIVE IN URBAN FIELD PRACTICE AREA OF GIMS, KALABURAGI

http://dx.doi.org/10.5530/ijmedph.2024.2.45

Sanjeevakumar Bavule, Gururaj NA, Basavakumar Anandi, Ajaykumar G, Pavan S Kalasker

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Background: Passive smoking is associated with around 0.6 million deaths worldwide each year. Over one-third of the population is frequently exposed to cigarette smoke, either directly or indirectly. Smoking by parents in the presence of their children is seen as a serious public health concern. Although the hazards associated with smoking are well established, many parents still choose to smoke around their children. Objectives: The objective of this study was to estimate the prevalence of smokers and to assess the parents’ knowledge and practice about passive smoking. Material and Methods: A community based cross-sectional study was carried out by random selection of 300 subjects from four wards in the urban field practice area of GIMS (Gulbarga institute of medical sciences) Kalaburagi, in October 2023 to January 2024.Data was collected using a pretested, semi-structured questionnaire and were entered and analysed in MS excel 2019. Results and Conclusion: 31%, 58.3% and 10.7% of subjects were having good, average and poor knowledge respectively and 43.7% of subjects were current smokers. Knowledge was significantly associated with age groups, education, occupation and socio-economic status. 58.8% were having satisfactory practices of passive smoking. The aggressive campaigns and programs need to be undertaken to enhance awareness about passive smoking among parents. Keywords: Knowledge, Practice, Passive smoking, Parents Perspective.

Page No: 218-222 | Full Text

 

Original Research Article

OUTBREAK INVESTIGATION OF VARICELLA-ZOSTER AMONG HOSTEL INMATES AT TERTIARY CARE CENTRE, KALABURAGI, KARNATAKA: A CASE-CONTROL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.46

Sangita S, Ramesh H, Basavakumar Anandi, Gururaj NA, Ajaykumar G, Pavan S Kalasker

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Background: Varicella (chickenpox) is a febrile rash illness resulting from a primary infection with the varicella-zoster virus (VZV). The disease is more prevalent in children than adults. Adults when affected manifest severe symptoms. Material and Methods: Following a sudden increase in cases in April 2023, an outbreak investigation and a matched case-control study were conducted, to assess the risk of varicella transmission among hostel inmates of a tertiary care center in Kalaburagi. Based on the clinical diagnosis, 8 cases and 32 controls matched for gender and year of course were chosen. The survey was conducted using an epidemiological case sheet, containing students' sociodemographic profile and clinical history, after obtaining written consent. Data was entered in an Excel sheet and analysed using JAMOVI software. The outbreak was described in terms of time, place, and person using descriptive statistics. The odds ratio was calculated to assess the strength of the association between risk factors and varicella infection. Results: The index case, 22 years old was detected on 7th April,2023 in boys hostel following which 7 more students were affected with a secondary attack rate of 6.93%. Mean (SD) age of cases was 20.13(1.36) years and males (75%) were most commonly affected. Majority (62.5%) presented with moderate lesions with none developing complications. All cases were identified and isolated (mean duration of 12.75(3.93) days) with strict precautions. Personal protective measures usage was significantly protective against varicella among risk factors, with an odds ratio of 0.09 (95% CI 0.01,0.51). Conclusion: With the help of active case finding, isolation, and vaccination campaigns, the outbreak was successfully controlled. Keywords: Varicella Zoster, Outbreak, Hostel, Case-Control study.

Page No: 223-227 | Full Text

 

Original Research Article

TO INVESTIGATE THE RELATIONSHIP BETWEEN CLINICAL, SONOLOGICAL, AND HISTOLOGICAL FACTORS IN PATIENTS WITH RIGHT ILIAC FOSSA PAIN WHO UNDERWENT APPENDECTOMY

http://dx.doi.org/10.5530/ijmedph.2024.2.47

Amit Agarwal, Karan Koul, Shashi Kumar Chaurasiya, Rajiv Verma

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Background: Appendicitis is a frequent source of discomfort in the right iliac fossa, sometimes requiring emergency abdominal surgery. Despite clinical, intraoperative, radiographic, and histo-pathological observations, the presence of non-perforating or non-acute types of appendicitis is still questioned. Although appendectomy is considered curative, the scheduling of the procedure remains debatable, particularly in cases of non-acute appendicitis. Aim: To investigate the relationship between clinical, sonological, and histological factors in patients with right iliac fossa pain who underwent appendectomy. Material and Methods: This study was conducted on 30 cases with probable appendicitis who had appendectomy in the department of general surgery. The research included all patients who presented with right iliac fossa discomfort and underwent appendectomy. Results: The mean age was 26.46 with a standard deviation of 3.37. Within the research group, 24 patients had symptoms that indicated they had previously experienced acute appendicitis, whereas 6 patients did not have any indication of such a history. Ultrasonographic probe tenderness was seen in 22 instances, whereas it was not observed in 8 cases. The histopathology report indicated acute illness in 10 instances, accounting for 33.33% of the total, whereas chronic disease was seen in 20 cases, accounting for 66.67%. The research revealed that the ultrasonographic results had a sensitivity of 100% and a specificity of 45.50% when compared to the clinical diagnosis of appendicitis. Among the total of 15 chronic cases, 50% showed no probe discomfort, indicating a poor level of specificity. Out of the 16 patients who had moderate rebound discomfort in the right iliac fossa, indicated by a positive sign, none of them had acute inflammation of the appendix, but all 16 patients had chronic inflammation of the appendix. The investigation revealed that the surgeon's observations exhibited a sensitivity of 100% and a specificity of 90%. The X2 test yielded a P value that was determined to be very significant. Conclusion: Our research supports the suggestion made by others that there are distinct forms of appendicitis - perforating and non-perforating. Furthermore, we found that resolving episodes are indicative of non-perforating appendicitis attacks. It is crucial to identify non-acute/non-perforating variations because if surgical intervention is not performed, it may lead to prolonged symptoms, perforation, and wasteful procedures for other diagnoses. Keywords: Appendicitis, discomfort, right iliac fossa, histo-pathological.

Page No: 228-233 | Full Text

 

Original Research Article

EXAMINING THE INFLUENCE OF SOCIOECONOMIC FACTORS ON CHILDHOOD OBESITY RATES IN URBAN VS. RURAL COMMUNITIES: AN OBSERVATIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.48

Bhooma Venkata Ramana, Rajendra prasad Yerrabadi, N. Devchand, M Ram Sagar Reddy

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Background: Childhood obesity is a global health challenge. Socioeconomic factors play a significant role in influencing obesity rates, with distinct variations observed between urban and rural communities. Objective: To investigate the influence of socioeconomic factors on childhood obesity rates in urban versus rural communities using an observational approach. Material and Methods: The study sampled 100 children aged 5-15 years, equally divided between urban and rural areas. Childhood obesity prevalence was determined through BMI classification. Data on socioeconomic status (SES), parental education levels, access to nutritional food, and physical activity levels were collected through questionnaires and surveys. Descriptive statistics were used to identify correlations between these factors and obesity prevalence. Results: Obesity Prevalence: Urban children had a higher obesity prevalence (36%) than rural children (28%). Socioeconomic Status: In urban communities, children from lower SES households had a 40% obesity rate compared to 32% in higher SES households. In rural communities, these rates were 36% (lower SES) and 20% (higher SES). Parental Education Levels: Urban children with parents having a high school education or less had a 45% obesity prevalence versus 20% for those with college-educated parents. In rural communities, these rates were 32% and 25%, respectively. Nutritional Food Access: Urban children with limited access to nutritional food had a 40% obesity prevalence compared to 24% for those with good access. Physical Activity Levels: Urban children with less than 60 minutes of daily activity had a 48% obesity prevalence versus 28% for those exceeding 60 minutes. Rural communities showed similar trends. Conclusion: The study highlights the significant impact of socioeconomic factors on childhood obesity rates. Tailored interventions addressing SES disparities, education, food access, and physical activity are crucial for managing obesity in urban and rural settings. Keywords: Childhood obesity, socioeconomic status, parental education, nutritional access, urban-rural comparison.

Page No: 234-238 | Full Text

 

Original Research Article

LONGITUDINAL OUTCOMES OF HERPES SIMPLEX VIRUS TYPE 2 INFECTION IN A GENERAL POPULATION: A COHORT STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.49

Duggirala S S Srinivas Prasad, Nagendra Naidu B, Tejkumar C, Gomkonda Prem Sagar, T S Mohana Rao

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Background: Herpes Simplex Virus Type 2 (HSV-2) is a prevalent sexually transmitted infection with varying clinical manifestations. Understanding the longitudinal outcomes is crucial for managing and mitigating its impact on individuals and public health. Material and Methods: In this cohort study, 100 participants from the general population were assessed over a defined follow-up period to determine the prevalence, symptomatic status, outbreak frequency, quality of life impact, treatment adherence, and transmission risks. Participants underwent serological testing and completed questionnaires regarding their symptoms, antiviral therapy, and quality of life. Results: Among the 100 participants, 32 tested positive for HSV-2, resulting in a prevalence rate of 32%. Of these, 22 (70%) were symptomatic, while 10 (30%) were asymptomatic. Symptomatic individuals experienced varying outbreak frequencies, with 31% suffering from 4-6 outbreaks annually. Quality of life was significantly impacted in symptomatic individuals across social (64%), psychological (68%), physical (42%), and financial (35%) domains. In the symptomatic group, 75% were on antiviral therapy, which effectively reduced outbreak frequency and severity. Viral shedding was detected in 31% of asymptomatic individuals, while 16% of asymptomatic individuals progressed to symptomatic during follow-up. Two partner transmission cases were recorded. Conclusion: The longitudinal outcomes of HSV-2 infection highlight the varied clinical course and significant psychosocial impact, underscoring the importance of consistent monitoring, individualized management, and effective educational programs to reduce transmission risk and improve patient outcomes. Keywords: Herpes Simplex Virus Type 2, Prevalence, Outbreak Frequency, Quality of Life, Antiviral Therapy, Transmission Risk.

Page No: 239-243 | Full Text

 

Original Research Article

A COMPARATIVE ANALYSIS IN THE SURGICAL OUTCOME OF BICONDYLAR TIBIAL PLATEAU FRACTURES TREATED WITH DUAL PLATING AND LATERAL LOCKING PLATE

http://dx.doi.org/10.5530/ijmedph.2024.2.50

Kumar esapathy. S, Manikandan. R, Praveen. B, Dhivakaran. D

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Background: Management of tibial plate fracture represents a challenging problem in developing countries. The objective of the current study is to analyze the functional and radiological outcome of bicondylar plateau fractures treated with dual plating and locking plate. Materials and Methods: This is a randomized controlled prospective study conducted in the Department of Orthopedics and Radiology at Mahatma Gandhi Government Hospital and Govt. K.A.P.V Medical College, Trichy on patients with closed Schatzker Type V and VI undergoing surgical fixation from October 2020 to September 2021. All the eligible subjects were recruited into the study consecutively by convenient sampling till the sample size is reached. Results: Atotal of 20 patients with Type V and VI Schatzker fracture undergoing surgery are divided into two groups with one group undergoing dual plating and the other lateral locking plate. The mean age was 49.1 ± 8.44 years in Dual plating group and 41.1 ± 8.74) years in Locking plate group. In Dual plating group, the functional knee society score was excellent 30%, good for 40% and fair for 30%. In locking plate group, excellent for 40%, good for 40% and fair for 20%. Conclusion: There was no statistically significant difference in functional knee society score and radiological score and outcome between the study groups (p value>0.05). For the treatment of bicondylar tibialplateau fractures, lateral locking plate fixation may yield clinical and radiological outcomes that are comparable to dual locking plate fixation. Keywords: Bicondylar, Tibial Plateau Fracture, Schatzker Types, Malunion, Dual Plating, Lateral Locking Plate.

Page No: 244-250 | Full Text

 

Original Research Article

A COMPARATIVE STUDY OF CONCOMITANT MEDIAL AND LATERAL MENISCAL INJURIES IN PATIENTS WITH ANTERIOR CRUCIATE LIGAMENT (ACL) INJURIES

http://dx.doi.org/10.5530/ijmedph.2024.2.51

Suresh Bora, Imran Hussain Kabir, Ali Akhtar, Sayan Mukherjee, Soumen Akhuli, Biswajit Das, Nishan Patra

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Background: Anterior cruciate ligament (ACL) is the major stabilizer of the knee. ACL injuries are frequently associated with meniscal injuries. Aim of this study is to compare the concomitant medial and lateral meniscal injuries in patients with anterior cruciate ligament (ACL) injuries. Materials and Methods: A hospital based cross-sectional study conducted with 70 individuals aged 19 to 50 who had ACL injuries. Clinical examinations were performed to identify ACL and other soft tissue injuries of the knee joint, and positive results were further assessed and confirmed by MRI. Results: 64.29% cases of ACL injury were associated with other concomitant soft tissue injuries. Medial meniscal injuries were the most frequent concurrent injury, occurring in 45.71% of cases, while lateral meniscus injuries were the second most prevalent, occurring in 37.14% of instances. It has been determined that there is a statistically significant correlation between the duration of time since trauma and the prevalence of medial meniscus injury. Concomitant injuries were shown to be statistically significantly associated with older age groups and patients who reported later after trauma. Conclusions: Prevalence of concomitant injuries more in patients who presented late after trauma. Prevalence of concomitant medial meniscus injury increases with increasing duration since trauma. However lateral meniscus injury most commonly seen in acute cases. Key words: ACL, meniscus, trauma, age.

Page No: 251-256 | Full Text

 

Original Research Article

A STUDY OF HPV, P16 EXPRESSION AND OXIDATIVE STRESS IN CERVICAL CANCER PATIENTS

http://dx.doi.org/10.5530/ijmedph.2024.2.52

Satya Prakash, Rajmangal Choudhary, Ishrat Fatima Majeedi, Sunita, Mahendra Singh, Manoj Kumar Rao

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Background: Cancer of the uterine cervix is one of the most common cancers among women worldwide and second only to breast cancer in incidence and mortality. Epidemiological and molecular studies have shown that human papillomavirus (HPV) infection is the most important factor for cervical carcinogenesis. The p16INK4a is a cyclin-dependent kinase inhibitor that decelerates the cell cycle by inactivating the cyclindependent kinases involved in the phosphorylation of the retinoblastoma protein (RB). Expression of E6 and E7 oncogenes of high-risk (HR) human papillomavirus (HPV), affecting the RB-p16 pathway, leads to p16 upregulation. Oxidative stress is an imbalance between the prooxidant-antioxidant system. A decrease in the level of antioxidants generated free radicals, which leads to DNA damage, causing dysfunction and disease. It is caused by a disturbed oxidant-antioxidant balance in favor of oxidants, leading to excessive generation of free radicals, particularly reactive oxygen species (ROS), and biological damages. Superoxide anion (O2•−), hydrogen peroxide (H2O2), and hydroxyl radical (• OH) are kinds of ROS that are produced by partial reduction of atmospheric O2. Material and Methods: This study is hospital based study examined at the Department of Pathology and Biochemistry at Tertiary Care Teaching Hospital. On a population of 70 consecutive patients who were diagnosed with PCV, and subsequently treated at Hospital. To get two groups with a significant difference in survival, patients with PCV were divided into short-term survivors (dying within ⩽2 years of diagnosis) and long-term survivors (surviving ⩾8 years after diagnosis). All tumour biopsies were fixed in buffered formaldehyde, paraffin-embedded and diagnosed on haematoxylin and eosin-stained tissue sections. For the present study, four sections from each archived tumour biopsy were prepared and used for histological diagnosis and immunohistochemistry (thickness: 4 μm). Sections for haematoxylin and eosin staining were prepared before and after each section to confirm tumour representativity. Results: HPV types and status in correlation with clinical parameters and expression of p16. Sixty-five out of 70 patients with PCV could be evaluated for HPV status. 16 were positive for high-risk HPV and 49 were HPV negative. The majority (10 out of 16, 62.5%) of HPV-positive patients were positive for HPV16. The others were positive for HPV45 (2 patients, 12.5%), HPV18 (1 patient, 6.2%), HPV35 (1 patient), HPV56 (1 patient), and HPV68 (1 patient). Human papillomavirus positivity was significantly correlated with strong p16 expression (p= 0.045). In all, 9 out of the 49 HPV-negative patients were negative for p16 immunostaining, while the remaining 83% showed varying expression: 3 Conclusion: The vast majority of HPV positive vaginal cancers showed p16 overexpression, suggesting active involvement of HPV in the malignant transformation process. Keywords: Human papillomavirus, Cervical intraepithelial neoplasia (CIN), p16, Ki-67, p63.

Page No: 257-263 | Full Text

 

Original Research Article

COMPARISON OF PREEMPTIVE ANALGESIA WITH TWO DOSES OF PREGABALIN IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY

http://dx.doi.org/10.5530/ijmedph.2024.2.53

Vijaya Durga S, Muneer Ahmed T, Chalapathy P, Lakshmi Praveena B, Sunil C

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Background: Management of post-operative pain has become inevitable with focus on newer methods of pain relief, and one among such methods is preemptive analgesia. Preemptive analgesia with different drugs as a part of a multimodal approach in cases of laparoscopic cholecystectomy is in vogue. This study focuses on the pre-emptive analgesic effect of different doses of Pregabalin on patients posted for laparoscopic cholecystectomy given in the pre-operative period. Material and Methods: A total of 60 ASA grade I and II patients of either sex posted for laparoscopic cholecystectomy were randomly divided into two groups. GROUP A patients received 150mg oral pregabalin, and GROUP B patients received 225mg oral Pregabalin 1.5 hours before surgery. We monitored postoperative VAS scores, intubation response, first rescue analgesia time, total analgesic requirement, RAMSAY sedation score, perioperative hemodynamics, side effects. Results: We have found that there is a significant difference between the two groups with respect to post-operative VAS scores(p<0.05). Though there is a difference between Heart Rate, MAP, Ramsay sedation score, and side effects, the difference is non-significant. Conclusion: Preemptive analgesic effect with 225mg oral pregabalin is a better alternative to pregabalin 150mg with comparable side effects. Keywords: Preemptive analgesia, Pregabalin, VAS score, MAP, Ramsay sedation score.

Page No: 264-270 | Full Text

 

Original Research Article

COMPARATIVE STUDY OF DEXMEDETOMIDINE AND PROPOFOL FOR MONITORED ANAESTHESIA CARE IN PATIENTS UNDERGOING CATARACT SURGERY

http://dx.doi.org/10.5530/ijmedph.2024.2.54

Karkala Srikanth Reddy, Divya Puskur, Sherry Mathews, Deepraj Singh

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Background: The present study is undertaken to perform a comparison and evaluation of efficacy of dexmedetomidine and propofol as an appropriate sedative drug for Monitered Anaesthesia Care (MAC) in patients undergoing cataract surgery under day care basis in Bhaskar General hospital. Material and Methods: A total of 60 patients between the age group of 20-75 years were included in the study. They were ASA I, II or III and scheduled for the cataract surgery under MAC. After obtaining approval from the ethical committee and obtaining informed consent, patients were randomly divided into two groups, as group D(n=30) and group P(n=30) to receive dexmedetomidine and propofol respectively. Patients fasted at least 8 hours before operation and did not receive any pre-operative sedative drug. Topical anaesthesia using the sterile 0.5% proparacaine hydrochloride ophthalmic solution was applied to the eye of the patients to be operated. Group D consisted of 30 members with equal male and female distribution. These patients received Dexmeditomidine infusion of 0.6mcg/kg/hr and titrated every 5 minutes to maintain Ramsay sedation scale 3 during the operation and the drug was adjusted by the 0.1mcg/kg/hr. Group P consists of 30 members, with equal male and female distribution. These patients received propofol infusion of 2mg/kg/hr and titrated every 5 minutes to maintain Ramsay sedation scale 3 during the operation and the drug was adjusted by 0.3mg/kg/hr. The infusion was stopped at the end of the surgery in both groups. In the postoperative ward, patients were asked to answer the 11 questions of Iowa satisfaction with anaesthesia scale (ISAS) using a 6-point rating scale at least 1 hour after the operation. It was performed by one anaesthesiologist who was blinded to the group assignment. Results: In the present study, MAP, HR, respiratory rate (RR), and peripheral oxygen saturation (SpO2) were recorded at each time point as follows; T1 = preoperative baseline, T2 = anaesthesia start, T3 and T4 = 5 and 10 min after anaesthesia, T5 = operation start, T6, T7, and T8 = 5, 10, and 15 min during operation, T9 = postoperative value. MAP, HR, RR, SPO2 were compared between the 2 groups, group D and P at various time points from T1-T9 were found not to be statistically significant as p>0.05. ISAS of group D is 53.50 ±2.193 and ISAS of group P is 43.10 ±2.090. The p value between the 2 study groups is 0.0001 which is highly statistically significant. Ramsay sedation scale of 3 was maintained throughout the operation in both the study groups. Conclusion: The study showed that dexmedetomidine seems to be a appropriate sedative drug with better patient satisfaction scores for MAC compared to propofol in patients undergoing cataract surgery. Keywords: Monitered Anaesthesia Care,Propofol, Dexmedetomidine,Iowa Satisfaction with Anaesthesia scale,Ramsay sedation score, Cataract.

Page No: 271-278 | Full Text

 

Original Research Article

INVESTIGATING THE CORRELATION BETWEEN SERUM BIOMARKERS AND DISEASE SEVERITY IN TYPE 2 DIABETES MELLITUS: AN OBSERVATIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.55

Deepak Kumar, Bhagyashree K Bhuyar, Soujanya Karpay, Deepthi Kondu

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Background: Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease. This study investigates the correlation between various serum biomarkers and disease severity to better understand disease progression. Material and Methods: An observational study was conducted with 100 T2DM participants (52 males, 48 females) aged 40-70. Participants were classified into mild, moderate, and severe categories based on clinical evaluation. Serum biomarkers such as fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), C-reactive protein (CRP), lipid profile, serum creatinine, and microalbuminuria were measured. The correlation between each biomarker and disease severity was assessed using Pearson’s correlation coefficients. Results: Significant positive correlations were observed between FPG (r = 0.68, p < 0.001), HbA1c (r = 0.72, p < 0.001), CRP (r = 0.54, p < 0.01), triglycerides (r = 0.58, p < 0.01), serum creatinine (r = 0.48, p < 0.01), and microalbuminuria (r = 0.63, p < 0.001) with disease severity. In contrast, HDL cholesterol was inversely correlated (r = -0.37, p < 0.05) with severity. Higher levels of these biomarkers were associated with greater disease progression from mild to severe. Conclusion: The study identifies significant correlations between T2DM disease severity and key serum biomarkers. Elevated levels of FPG, HbA1c, CRP, triglycerides, serum creatinine, and microalbuminuria indicate increased disease severity. Conversely, HDL cholesterol is inversely associated. These biomarkers provide critical insights into disease progression and can aid in risk stratification and targeted intervention. Keywords: Type 2 diabetes mellitus, fasting plasma glucose, glycated hemoglobin, C-reactive protein, lipid profile.

Page No: 279-283 | Full Text

 

Original Research Article

COMPARISION OF TWO DIFFERENT RADIO THERAPY FRACTIONATION SCHEDULES FOR METASTATIC SPINAL CORD COMPRESSION

http://dx.doi.org/10.5530/ijmedph.2024.2.56

Motepalli Pandu Ranga Kumari, Karra Pradeep, Vijaya Radhika Pyda, Gundavarapu V Lakshmikeerthana, Nitya Aishwarya Titty, Venkata Suresh Anga

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Background: Indian population experiences cancers of Lung, Breast, prostate most commonly where the disease is systemic to start with, and a high chance of metastasis to bones. Our institute experience most common radiotherapy emergency of spinal cord compression so regularly that we need to frame a protocol for this cases on priority basis and to save the linac machine time is also so precious. Objectives: To compare the overall response in patients treated with two different fractionation schedules of 4 Gy x 5 fractions versus 3 Gy x 10 fractions for metastatic spinal cord compression. Materials and Methods: It is a prospective comparative study with total number of patients enrolled in the study is 60. After obtaining informed consent, then patients were enrolled in the study. Patients with known biopsy proven tumour presenting with metastatic spinal cord compression causing lower limb motor dysfunction. Results: Results showed that overall response to radiation and ambulatory status of patients post irradiation were similar in both arms. There was no significant difference between the arms. Conclusion: Comparatively no difference in over all response and ambulatory status of patient by different fractionation. In general patients with MSCC have a poor survival and short course fractionation with 4 Gy x 5 fractions can be considered instead of the standard 3 Gy x 10 fractions. Keywords: Bone secondaries, spinal cord compression, palliative radiotherapy,30Gy/10 frctions,20 Gy /five fractions

Page No: 284-290 | Full Text

 

Original Research Article

TO ASSESS THE SIGNIFICANCE OF TLC, ANC, NLR, AND ABDOMINAL ULTRASONOGRAPHY IN PATIENTS DIAGNOSED WITH ACUTE APPENDICITIS

http://dx.doi.org/10.5530/ijmedph.2024.2.57

Tarun Narang, Shweta, Sebin Sebastian, Chiranjeev Gathwal

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Background: The diagnosis of acute appendicitis is mostly based on clinical assessment, and prompt action is crucial. Early detection may lead to unnecessary removal of the appendix, while delayed diagnosis can result in complications. Several criteria were periodically examined, but none of them could definitively be considered 100% accurate. Aim: To evaluate the role of total leucoycte count (TLC), absolute neutrophil count (ANC), neutrophil lymphocyte ratio (NLR) and ultrasound abdomen in patients with clinical diagnosis of acute appendicitis. Materials and Methods: The study was conducted on 100 patients. Patients with clinical features of acute appendicitis aged between 15 and 65 years were included in this study. he neutrophil Lymphocyte ratio would be obtained by dividing the percentage of neutrophils to the percentage of lymphocytes from the data available from differential leukocyte count. All patients was subjected to ultrasound examination of abdomen. Based on evidence in medical literature diagnostic categories for ultrasound abdomen are as follows. Results: 86 cases (86%) had histopathologically proven features of acute appendicitis. There were 4 cases (4%) of gangrenous appendix. Congestion of appendix (normal appendix) was seen in 14 cases (14%). 90 Patients (90%) was diagnosed to have acute appendicitis by ultrasonography. Ultrasound could diagnose appendiceal perforation in 6 cases (6%). Probable appendicitis was given in 11 cases (11%) and normal appendix in 7 (7%) of cases. Appendix could not be visualised in 3 cases (3%). Out of the total 90 cases diagnosed as acute appendicitis by ultrasound only 78 cases were histopathologically proven appendicitis. Neutrophil lymphocyte ratio (NLR) categorised as number of cases with NLR between 0 -2.5, 2.5 to 5, 5 – 7.5 and 7.5 and above. There were 17 (17%) ,63 (63%), 12 (12%), 8(8%) cases in each of these cases respectively. Out of the 86 cases of acute appendicitis 16 patients had NLR between 0-2.5 and remaining 70 patients had NLR > 2.5. 49 patients had NLR between 2.5 to 5, 9 patients with NLR between 5 to 7.5 and 8 patients with NLR > 7.5. TLC was elevated in 8 out of the 14 cases of negative appendicectomy. ANC was elevated in 11 out of 14 cases of negative appendicectomy. NLR was elevated in 13 out of 14 cases of negative appendicectomy. There was one case in which all the parameters were normal in the study and histopathology was positive for appendicitis. Conclusion: We concluded that total leucocyte count is a not specific marker for predicting acute appenditicitis, though absolute neutrophil count and neutrophil lymphocyte ratio are better markers for predicting acute appendicitis. Ultrasound of abdomen has 90% accuracy rate in predicting acute appendicitis. Keywords: Total leucoycte count, Absolute neutrophil count, Neutrophil lymphocyte ratio, Ultrasound abdomen, Acute appendicitis.

Page No: 291-297 | Full Text

 

Case Series

UTERINE RUPTURE - MATERNAL AND FETAL OUTCOME: A RETROSPECTIVE CASE SERIES AT A TERTIARY CARE CENTRE

http://dx.doi.org/10.5530/ijmedph.2024.2.58

Ashwini Pawar, Surekha S M, B. H. Narayani, Suman Patil

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Background: Uterine rupture is a rare but life-threatening condition in obstetrics. It is the total disruption of the wall of the gravid uterus with or without extrusion of its contents, associated with high maternal and fetal morbidity and mortality. Aims and Objectives: 1. To observe the maternal outcome in the cases of uterine rupture. 2. To observe the fetal outcome in cases of uterine rupture. Materials and Methods: A retrospective study of total of 8 cases (from August 2023 to January 2024) in KIMS KOPPAL diagnosed with uterine rupture and maternal and fetal outcome noted and followed up. Results: Among 8 cases, 7 cases required emergency caesarean section, ICU admission and multiple blood and blood products transfusion whereas one case ended up in maternal mortality. Of the total cases, 2 cases required neonatal ICU admission whereas, remaining 6 cases had neonatal mortality because of complete uterine rupture. Conclusion: Uterine rupture is one of the important reasons for contributing to maternal and neonatal mortality. Identification of the high-risk pregnancies, early diagnosis, immediate referral and prompt management must be undertaken to avoid and reduce adverse feto-maternal outcome. Keywords: Uterine Rupture, Feto-Maternal Outcome, Mortality, Caesarean Section.

Page No: 298-300 | Full Text

 

Original Research Article

A HOSPITAL BASED OBSERVATIONAL STUDY TO DETERMINE THE PSYCHIATRIC MORBIDITY, SUBSTANCE USE, QUALITY OF LIFE IN PERSON WITH EARLY ONSET AND LATE ONSET DEMENTIA

http://dx.doi.org/10.5530/ijmedph.2024.2.59

Suman, Gaurav Rajender, Akash R, Deepa Chaudhary, Mona Narain, Alok Tyagi

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Background: Dementia is typically defined as a clinical syndrome of cognitive decline that is sufficiently severe to interfere with social or occupational functioning. Early onset dementia (EOD) patients differ from late onset dementia (LOD) patients on a number of clinical, neuropsychological, neuropathological, and neuroimaging variables. With this background, the current research was done to determine the psychiatric morbidity, substance use, quality of life in persons with early onset and late onset dementia and to compare the differences in above factors between early onset and late onset dementia. Material and Methods: This is a hospital based prospective study done on 50 Patients attending the department of psychiatry, SMS Medical College, Jaipur, Rajasthan, India during one-year period. Study sample had been grouped into two categories as early onset and late onset dementia (25+25) based on the age of onset (< 65). DEMENTIA SEVERITY RATING SCALE will be administered to grade the severity of dementia. Psychiatric comorbidity and substance use were assessed using MINI PLUS INTERNATIONAL NEUROPSYCHIATRY INTERVIEW scale. Quality of life was measured using DEMQOL & DEMQOL proxy scale. Data was entered into excel and analyzed using SPSS v 16.0. Mean and standard deviation were calculated to summarize continuous variables such as age, DSRS scores and DEMQOL scores Number and percentage was used to present the categorical data pertaining to the following distribution of the various socio-demographic variables, types of psychiatric co-morbidities and dementia. Results: Our study showed that the patients in late onset category were significantly older than the other group. However, majority of the patients in early onset were males (64%) and hence a little more half of the patients (52%) were accompanied by their wife. There was statistically significant higher DSRS scores (p<0.05) among those in early onset group on comparison with the late onset group. In line with the DSRS scores, the quality of life as measured by the DEMQOL scale was significantly higher (p<0.05) in late onset dementia group on comparison with early onset dementia group. All the subscales of DEMQOL construct had significantly higher scores in patients with late onset dementia. Conclusion: We concluded that participants with both early and late onset dementia had no significant differences in psychiatric co- morbidities and substance abuse. However, those with early onset dementia had significantly higher DSRS scores and less QOL scores indicating higher functional disabilities and the need for early intervention in this subgroup for better quality of life. Keywords: Early Onset Dementia, Late Onset Dementia, QOL, DEMQOL, DSRS, MINI Plus scale.

Page No: 301-307 | Full Text

 

Original Research Article

ANTEPARTUM ECLAMPSIA AND PREGNANCY OUTCOME IN TERTIARY CARE HOSPITAL: A RETROSPECTIVE OBSERVATIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.60

Dhole Mahananda Subhanrao, B. H. Narayani, Seema B. N, Srajana

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Background: Antepartum eclampsia is one of the medical disorders complicating pregnancy and the leading cause of maternal and perinatal mortality as well as morbidity. Aim and Objectives: 1) To evaluate rate of eclampsia in antenatal women attending our hospital. 2) To analyse maternal and perinatal outcome in women with eclampsia. Material and Methods: This retrospective observational study was carried out at a tertiary care institute from Sept 2023 to Feb 2024. Results: Young primigravida is a major high-risk factor in eclampsia. Conclusion: Eclampsia is a preventable risk factor if preeclampsia diagnosed in ANC. Keywords: Eclampsia, Pregnancy Outcome, ANC Care.

Page No: 308-310 | Full Text

 

Original Research Article

EFFECT OF ORAL PREGABALIN AS PREMEDICATION ON LARYNGOSCOPY RESPONSE: A RANDOMIZED PLACEBO CONTROLLED TRIAL

http://dx.doi.org/10.5530/ijmedph.2024.2.61

Amanpreet Singh, Jyoti Sharma, Ruchika Kathuria, Shubham Bhardwaj

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Background: Pregabalin is a novel drug that exhibits analgesic, anticonvulsant, and anxiolytic properties by decreasing the levels of neurotransmitters such as glutamate, noradrenaline, serotonin, dopamine, and substance P. Hence, the present study was undertaken to determine the role of oral pregabalin as premedication on attenuation of stress response to laryngoscopy. Materials and Methods: The present study was conducted among 100 patients who underwent elective surgery under general anaesthesia. Patients were randomly assigned in two groups of 50 each. Group P patients were administered oral pregabalin at a dosage of 150 mg, while group C patients were given oral placebo in the form of oral multivitamin tablet. The study recorded heart rate (bpm) and non-invasive measurements of systolic blood pressure (mmHg), diastolic blood pressure (mmHg), and mean arterial pressure (MAP) (mmHg) at various time points. A significance level of P < 0.05 was used to determine statistical significance. The analysis was conducted using the SPSS statistical tool version 20.0 (IBM in Armonk, NY). Results: Heart Rate increased significantly after laryngoscopy and tracheal intubation in all groups (P<0.05). However, the increase in heart rate was significantly lower in pregabalin group compared to the placebo group (P<0.05). Systolic blood pressure was higher from baseline values in control group during laryngoscopy (p = <0.05). Thereafter, this upsurge remained persistent throughout the surgery at all points of time till 10 minutes after laryngoscopy (p <0.05). In the pregabalin group, there was no increment, and the patients were stable at all points of time after giving the study drug with similar trend observed for diastolic and mean blood pressure. Conclusion: Pregabalin effectively reduces the physiological stress response to laryngoscopy. Keywords: Haemodynamic Stress Response; Laryngoscopy; Pregabalin.

Page No: 311-316 | Full Text

 

Original Research Article

STUDY OF COMPARATIVE EVALUATION OF THE EFFECT OF BUPIVACAINE AND ROPIVACAINE IN CESAREAN DELIVERY WITH SPINAL ANESTHESIA

http://dx.doi.org/10.5530/ijmedph.2024.2.62

Hinaben Kanubhai Patel, Dharmendra Shandilya, Priyanka. K, Jigishaben Dipal Kumar Rathod

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Background: Cesarean section is the most frequent obstetric operation that is performed in cases when a vaginal delivery would put the fetus or mother at risk. Hence, the present study was conducted for comparing the Effect of Bupivacaine and Ropivacaine in Cesarean Delivery with Spinal Anesthesia. Materials & Methods: 50 patients who were planned for a spinal anesthetic elective cesarean delivery were randomized into two study groups: one for ropivacaine and the other for bupivacaine. The process of administering spinal anesthesia was done while seated. Five-minute intervals were used for the assessment of the sensory block levels. The pinprick test was used to gauge the degree of sensory blockage. A visual analog scale (VAS) was used to measure the patients' pain intensity. It ranged from 0 (no discomfort) to 10 (severe pain). Data were presented as frequency, percentages, mean, or standard deviation wherever applicable. Chi square test was used to assess categorical variables between the groups. Results: Both the study groups were comparable in terms of age-wise distribution. Compared to the ropivacaine group, the bupivacaine group had sensory block onset much more quickly. Compared to the bupivacaine group, the ropivacaine group experienced total sensory blockade substantially faster. Non-significant results were obtained while comparing the pain among two study groups. Conclusion: In comparison to bupivacaine, ropivacaine produced a similar and successful clinical profile with a shorter duration of sensory block for elective cesarean sections; nevertheless, the onset time of ropivacaine's sensory blockage was much greater than that of bupivacaine. As a result, ropivacaine may be used during cesarean sections instead of bupivacaine. Keywords: Bupivacaine, Ropivacaine, Caesarean.

Page No: 317-319 | Full Text

 

Original Research Article

LAPAROSCOPIC NEPHRECTOMY IN BENIGN KIDNEY DISEASE: EXPERIENCE OF 104 CASES

http://dx.doi.org/10.5530/ijmedph.2024.2.63

Pankaj Trivedi, Vishvas Baheti, Anil Kumar Bhiwal, Pushpendra Choudhary

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Background: Laparoscopic nephrectomy has been increasingly popular as a suitable treatment option for patients who are carefully chosen. It was consistently demonstrated that laparoscopic nephrectomy is equally successful to open surgical extirpation and is more easily tolerated than open surgery. Here we have retrospectively analysed experience of 104 cases of laparoscopic nephrectomy in benign disease over the last 4 years in tribal region of south Rajasthan. Materials & Methods: Between July 2019 to July 2023, we retrospectively collected all data from our database and analysed total patients who underwent laparoscopic simple nephrectomy at our institution for benign kidney pathology. We reviewed demographics, indications, preoperative parameters, peri operative records, hospitalisation, complications and follow up. Results: A total of 104 patients underwent laparoscopic simple nephrectomy for benign pathology. Mean age of the 104 patients underwent laparoscopic simple nephrectomy was (range 18-76 years). Male to female ratio was 46 :58 (44.23% v/s 55.76 %). Mean estimated blood loss was 160ml which ranges from 15ml to 400ml. Mean duration of analgesic requirement was 3.8 days range from 1.5 to 5 days. Mean hospital stay was 3.6 days (range 36 hours to 10 days). 4 out of 104 (3.84%) patients required conversion to open nephrectomy. Conclusion: Laparoscopic nephrectomy has emerged as a significant adjunct to well-established surgical methods. Due to its high level of safety and ability to be consistently replicated, laparoscopic nephrectomy has become the established method of treatment and should be made available to all patients with non-cancerous kidney conditions who are undergoing planned kidney removal surgery. Keywords: Benign Kidney Disease; Laparoscopic Nephrectomy; Renal Calculus Disease; PUJ Obstructive Nonfunctioning Kidney (NFK).

Page No: 320-323 | Full Text

 

Original Research Article

ASSESSING ENDOTHELIAL DYSFUNCTION THROUGH SHEAR STRESS: IMPLICATIONS FOR CARDIOVASCULAR HEALTH

http://dx.doi.org/10.5530/ijmedph.2024.2.64

Priyanka Katara, Dhiraj Saxena, Ashish Trivedi, Nauratmal Kumawat, Devasheesh Sharma, Anirudh Saxena

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Background: Atherosclerosis, the precursor to many CVD forms, underscores the pivotal role of the vascular endothelium. Endothelial dysfunction, closely tied to conditions like coronary artery disease (CAD), hypertension, and diabetes mellitus, emerges as a critical clinical concern preceding histological signs of atherosclerosis. Within the vascular system, the equilibrium of vasodilatory and vasoconstrictor substances is paramount for vascular tone regulation, with nitric oxide (NO) showcasing significant vasodilatory effects. The endothelial response to increased shear stress results in an active release of vasoactive substances, crucial for vascular homeostasis. In cases of endothelial dysfunction, this delicate balance is disturbed, potentially leading to various vascular pathologies. Materials and Methods: The study's investigational focus revolves around the potential of shear stress assessment in the brachial artery as a surrogate marker for cardiovascular risk. By evaluating shear stress through non-invasive means, the study aims to ascertain its feasibility as a cost-effective screening test for identifying cardiovascular disease risk. Results: The data indicates that the shear stress values at both baseline and during hyperemia phases do not significantly differ between the Control and Case groups. This lack of statistical significance suggests that shear stress may not be a differentiating factor related to endothelial function or vascular health in this study. Other variables or factors may be more influential in distinguishing between the two groups regarding cardiovascular health and endothelial function. Conclusion: The data indicates that the shear stress values at both baseline and during hyperemia phases do not significantly differ between the Control and Case groups. This lack of statistical significance suggests that shear stress may not be a differentiating factor related to endothelial function or vascular health in this study. Other variables or factors may be more influential in distinguishing between the two groups regarding cardiovascular health and endothelial function. Keywords: Brachial Artery, Endothelial Dysfunction, Flow Mediated Dilation, Shear Stress, Hemodynamics.

Page No: 324-328 | Full Text

 

Original Research Article

A HOSPITAL BASED PROSPECTIVE STUDY TO COMPARE THE KANGAROO MOTHER CARE (KMC) WITH CONVENTIONAL METHOD OF CARE (CMC) IN THE CARE OF LOW BIRTH WEIGHT INFANTS (LBWI) AT TERTIARY CARE CENTER

http://dx.doi.org/10.5530/ijmedph.2024.2.65

Priyanka Singh, Fauzia Arif, Naresh Kumar

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Background: Low birth weight (LBW) is a global problem particularly in developing countries. Kangaroo mother care is defined as early, prolonged & continuous skin to skin contact between mother and baby. Our aim of this study to compare the Kangaroo mother care (KMC) with conventional method of care (CMC) in the care of low birth weight infants (LBWI) at tertiary care center. Materials & Methods: A hospital based randomized controlled study was conducted in Department of Pediatrics, JNUIMSRC, Jaipur, Rajasthan, India during one-year period. The study population included 80 consecutive singleton intramural neonates with birth weight <2000g. 40 infants who fulfilled the inclusion criteria were selected in each group. Group 1 receiving Kangaroo mother care and Group 2 receiving Conventional method of care in open radiant warmers. For the physiological parameters, the average readings in the KMC and CMC group for each parameter (oxygen saturation, temperature and weight gain) were compared with by unpaired, two-tailed 't' test and chi2 test wherever applicable. The analysis was done using the SPSS version 21.0 for windows. Results: The mean saturation of oxygen was 94.56% whereas in the CMC group it was 92.68% with a ‘p’ value of <0.01 which is statistically significant. The mean daily weight gain in the KMC group was 9.29 grams as against 7.13 grams in the CMC group with a ’p’ value of 0.0001. The mean body temperature in the KMC group was 37.180c as against 37.020c in the CMC group which is not statistically significant. The episodes of hypothermia measured twice a day for one week were 120 in the KMC group (17.15%) as against 160 (22.85%) in the CMC group with relative risk in the CMC group being 1.33 times that in KMC group. Conclusion: We conclude that KMC improves growth in low birth weight infants and has a significant role in protecting the LBW infant from hypothermia, hypoglycemia and sepsis. The present study has important implications in the care of LBW infants in the developing countries, where expensive facilities for conventional care may not be available at all places. Keywords: KMC, CMC, LBW Babies, Hypothermia, Oxygen Saturation.

Page No: 329-332 | Full Text

 

Original Research Article

COMPARATIVE EVALUATION OF EPIDURAL AND GENERAL ANAESTHETIC TECHNIQUE FOR UROLOGICAL SURGERIES – A HOSPITAL BASED STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.66

Altafuddin Ahmed, Anjan Jyoti Ghosh, Alangkrita Sarmah, Jyotsna Dutta

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Background: Though General Anaesthesia has been the choice of Anaesthesia for performing various Urological surgeries from long time, Neuraxial Anaesthesia is also gaining popularity as a choice of technique over last few years. Our study was aimed to compare General Anaesthesia (GA) with Epidural Anaesthesia (EA)in patients posted for urological surgeries. Materials & Methods: After getting approval from Institutional Ethics Committee (H) and informed consent from the patients and attendants, 80 no of patients of ASA I and II age between 18 to 60 years undergoing urological surgeries were grouped in two groups of 40 no of subjects in each. Group GA received conventional General Anaesthesia and Group EA received Epidural Anaesthesia with Ropivacaine 0.75% at a dose of 3mg/kg admixed with 1microgm / kg of Dexmedetomidine. The cardio respiratory parameters, surgeon’s satisfaction, patient’s satisfaction, onset and duration of block and side effects were observed and documented. The data collected were analysed using students t test and chi square test for parametric data and Mann – Whitney U – test for nonparametric data. Value of p<0.05 as considered statistically significant. Results: The demographic data like age, sex, height, weight, bodymass index were comparable. The parameters like duration of surgery and anaesthesia were comparable. Postoperatively the VAS score was statistically significant at 60 minutes. The requirement of first rescue dose was significant statistically. Surgeon’s satisfaction was comparable but the patient’s satisfaction was significant statistically. Haemodynamic parameters like tachycardia, hypertension, bradycardia were statistically significant. Side effects like nausea, vomiting, headache were comparable statistically. Conclusion: Epidural Anaesthesia can be a good alternative and equally effective in patients undergoing major urological surgeries. This procedure can be adapted more confidently in patients where General Anaesthesia is contraindicated. Key words: Epidural Anaesthesia, Ropivacaine, Dexmedetomidine, General Anaesthesia, Urological surgeries.

Page No: 333-339 | Full Text

 

Original Research Article

PREVALENCE OF PHYSICAL ACTIVITY IN UNDERWEIGHT, OVERWEIGHT AND OBESE YOUNG ADULTS STUDYING IN DIFFERENT INSTITUTIONS IN SOUTH KERALA, DURING THE COVID -19 PANDEMIC

http://dx.doi.org/10.5530/ijmedph.2024.2.67

Ninan Vergis Punchamannil

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Background: The prevalence of overweight and obesity has increased substantially across the globe over the last decades especially in the youth. One third of the world’s population can now be categorised as being overweight. Another category of young adults that are going unnoticed are those who are underweight. They should be made aware about the health implications as a result of being physically unfit. Physical inactivity is an established risk factor for cardiovascular disease, cancer, and diabetes etc. Hence it becomes a matter of immense importance to find out the prevalence of physical activity among young adults especially during the pandemic. The purpose of this study is aimed to assess the prevalence of physical activity in underweight, overweight and obese young adults and also to inculcate this routine in their daily lives. Material and Methods: A cross sectional study was done on 260 participants(selected based on inclusion and exclusion criteria) falling in the age group18-25 years studying in different institutions in a district in South Kerala. Physical activity was being assessed using GPAQ version 2 questionnaire. The level of physical activity referred in the questionnaire in each domain was presented as metabolic equivalent (MET). Height, weight, and BMI, of each student along with demographic details was collected. Results: It was found that there was a 40% of study participants follow an almost sedentary lifestyle. It is seen that those who were obese were seen to be highly active (32.4%)compared to other groups. A large percentage individuals falling under the normal BMI category was seen to be either inactive (35.9 %)or following a lifestyle of low activity (29.1%). There was statistically significant association between BMI and physical activity. Conclusion: Almost 40% of the study participants fell in the inactive group while only 24% was found in the highly active group and 13.8% in the moderately active group. Amongst the inactive group majority were female participants. Significant association with inactive group and their BMI was found. Hence our study proves the need to make the youth enlightened about the need to be physically active and encouraging them to improve their activity levels for a healthy future Keywords: MET, GPAQ, BMI, Physical activity

Page No: 340-346 | Full Text

 

Original Research Article

UNDERSTANDING PATIENT SATISFACTION AND PERCEPTION IN OUTPATIENT DEPARTMENTS: INSIGHTS FROM A CROSS-SECTIONAL STUDY IN SOUTH INDIA

http://dx.doi.org/10.5530/ijmedph.2024.2.68

P. Sreedhar, MC. Amarnath Reddy, MV. Kiran Kumar, K. Siva Bala Naganjan

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Background: Patient perception and satisfaction regarding services provided in Outpatient Departments (OPDs) are integral components of healthcare quality assessment. Understanding the factors influencing patient satisfaction is essential for improving healthcare delivery and patient outcomes. Material and Methods: This cross-sectional observational study aimed to comprehensively assess patient perception and satisfaction in OPDs. A structured questionnaire, adapted from validated instruments including the Press Ganey Patient Satisfaction Survey, was administered to 467 adult patients attending OPDs in South India. Descriptive statistics, inferential analyses, and regression models were employed to analyze the data. Results: In our study, a total of 467 patients were included, with the majority distributed across the age groups of 31-45 years (42.8%) and 18-30 years (32.1%). A total of 378 patients (80.9%) were satisfied with the overall experience Higher communication quality (β = 0.54, p < 0.001) and perceived cleanliness (β = 0.48, p < 0.001) were associated with greater satisfaction, while longer wait times (β = -0.32, p = 0.003) correlated with decreased satisfaction. Demographic predictors such as gender and educational background also played significant roles, with male patients and those with higher educational attainment reporting higher satisfaction levels. Conclusion: This study underscores the importance of effective communication, reduced wait times, and facility cleanliness in enhancing patient satisfaction within OPDs. Tailoring interventions to address demographic disparities and focusing on improving communication and service efficiency can optimize patient experiences and healthcare delivery in OPD settings. Keywords: Patient satisfaction, Outpatient Departments, Communication quality, Wait times, Cleanliness, Healthcare delivery.

Page No: 347-352 | Full Text

 

Original Research Article

SAFETY ATTITUDES AND WORKPLACE VIOLENCE AMONG EMERGENCY ROOM DOCTORS: A CROSS-SECTIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.69

E. Ramanjaneyulu, B. Soujanya Kumar, B V Rao, M V. Kiran Kumar

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Background: Patient turnover and high-stress environments. In these settings, emergency room doctors play a pivotal role in delivering timely and efficient care to patients with diverse and often critical conditions. However, the demanding nature of emergency medicine, coupled with long working hours, high patient volumes, and exposure to various hazards, poses significant challenges to both patient safety and healthcare provider well-being. Understanding the safety attitudes of doctors working in EDs, particularly in the context of physical violence, is essential for identifying areas of improvement and implementing effective interventions to enhance patient care quality and promote a safer working environment. Material and Methods: A cross-sectional study was conducted among emergency room doctors. Participants were recruited using convenience sampling methods. A self-administered questionnaire was used to collect data, including demographic information and responses to the Safety Attitudes Questionnaire (SAQ), a validated instrument for assessing safety attitudes in healthcare settings. SAQ scores were analyzed using chi-square tests and analysis of variance (ANOVA), to examine differences based on demographic factors and exposure to violence. Results: A total of 73 doctors participated in the study. Significant differences in safety attitudes were observed based on gender (p = 0.0001), age group (p = 0.009), designation (p = 0.0001), and exposure to physical violence/threats (p < 0.0001). Male participants, older age groups, faculty members, and those not exposed to violence exhibited more positive safety attitudes. Overall, the highest mean SAQ scores were observed in Safety Climate (64.29 ± 13.88) and Stress Recognition (63.44 ± 10.79) categories, while the lowest scores were noted in Perceptions of Management (43.75 ± 5.72). Exposure to violence was associated with significantly lower SAQ scores. Conclusion: Improving communication, addressing deficiencies in management perceptions, and implementing strategies to prevent violence are crucial for promoting a positive safety culture and enhancing patient care quality in EDs. Keywords: Emergency department, Safety attitudes, Doctors, Workplace violence, Patient safety.

Page No: 353-358 | Full Text

 

Original Research Article

DECONTAMINATION INTERVENTIONS IN REDUCING MICROBIAL CONTAMINATION AND MULTIDRUG-RESISTANT ORGANISM PREVALENCE IN HOSPITAL ENVIRONMENTS: A COMPARATIVE STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.70

B. Soujanya Kumar, E. Ramanjaneyulu, B V Rao, K Siva Bala Naganjan

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Background: In healthcare settings, microbial contamination poses a significant threat to patient safety, leading to healthcare-associated infections (HAIs) and increased morbidity and mortality rates. Multidrug-resistant organisms (MDROs) further exacerbate this challenge, necessitating effective decontamination interventions to mitigate their spread. This study aimed to evaluate the efficacy of various decontamination interventions in reducing microbial contamination and MDRO prevalence within hospital environments. Material and Methods: Environmental sampling was conducted across different hospital areas, including intensive care units (ICUs), operating theaters, and patient rooms, before and after the implementation of decontamination interventions. Three decontamination interventions were evaluated: manual cleaning and disinfection, UV germicidal irradiation, and hydrogen peroxide vaporization. Around 400 surface swabs were collected from high-touch surfaces, and microbial load was quantified using culture-based methods and polymerase chain reaction (PCR) for MDRO detection. Results: Our findings revealed significant reductions in microbial contamination and MDRO prevalence following decontamination interventions. MDRO prevalence decreased by 39.4% in ICUs, 38.5% in operating theaters, and 29.0% in patient rooms post-decontamination. Hydrogen peroxide vaporization demonstrated the most significant reduction in MDRO prevalence (50.0%), followed by UV germicidal irradiation (17.2%) and manual cleaning and disinfection (21.2%). High-touch surfaces such as door knobs, bed rails, and bedside tables exhibited substantial reductions in microbial burden post-decontamination. Conclusion: The findings of this study highlight the efficacy of decontamination interventions in reducing microbial contamination and MDRO prevalence within hospital environments. Targeted decontamination strategies, particularly hydrogen peroxide vaporization, show promise in mitigating the spread of resistant pathogens and enhancing patient safety. Keywords: Decontamination, multidrug-resistant organisms, microbial contamination, infection control, hospital environment, healthcare-associated infections.

Page No: 359-364 | Full Text

 

Original Research Article

ANALYZING THE INFLUENCE OF SCREEN TIME ON SLEEP PATTERNS AMONG SCHOOL-AGED CHILDREN: A CROSS-SECTIONAL STUDY

http://dx.doi.org/10.5530/ijmedph.2024.2.71

Vinod Kumar P, Uday Kiran G, Hareesh R

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Background: The increasing prevalence of screen use among children has raised concerns about its potential impact on sleep health. Previous research suggests that excessive screen time may be linked to adverse sleep outcomes, but further investigation is needed to understand this relationship in school-aged children. This study aims to examine the influence of screen time on sleep patterns among school-aged children. Materials & Methods: A cross-sectional study was conducted with a sample size of 100 children (50 boys and 50 girls) aged 6 to 12 years. Data on screen time, sleep duration, sleep quality, bedtime, wake-up time, sleep latency, and daytime sleepiness were collected through questionnaires. Statistical analyses included t-tests, correlation analyses, and multiple regression analyses. Results: The average daily screen time was 3.2 hours, with boys averaging slightly more screen time than girls (3.4 vs. 3.0 hours; p = 0.07). The overall mean sleep duration was 8.1 hours, with children reporting ≥3 hours of screen time per day sleeping significantly less (7.6 hours) compared to those with <3 hours of screen time (8.6 hours; p < 0.01). Children with higher screen time also had lower sleep quality scores (mean = 5.4 vs. 6.8; p < 0.01), later bedtimes (10:15 PM vs. 9:30 PM; p < 0.05), later wake-up times (6:45 AM vs. 6:00 AM; p < 0.05), longer sleep latency (28 vs. 18 minutes; p < 0.01), and higher prevalence of daytime sleepiness (45% vs. 20%; p < 0.05). Correlation analysis showed a significant negative relationship between screen time and sleep duration (r = -0.45; p < 0.01) and a positive relationship between screen time and sleep latency (r = 0.39; p < 0.01). Multiple regression analysis indicated that screen time was a significant predictor of sleep duration (β = -0.38; p < 0.01) and sleep quality (β = -0.42; p < 0.01), controlling for age and gender. Conclusion: Increased screen time is associated with shorter sleep duration, poorer sleep quality, and other negative sleep outcomes among school-aged children. Interventions to reduce screen time may improve sleep health in this population. Keywords: Screen time, sleep patterns, school-aged children, sleep duration, sleep quality, sleep latency, daytime sleepiness.

Page No: 365-369 | Full Text

 

Original Research Article

A STUDY ON DISORDERS OF THYROID IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

http://dx.doi.org/10.5530/ijmedph.2024.2.72

Syed Abrar Kareem, Amtul Umama Suroor

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Background: Type 1 Diabetes Mellitus is a chronic endocrinological condition commonly affecting children and young adults. type 1 diabetes mellitus due to its autoimmune pathogenesis is frequently associated with autoimmunity to other hormones such as thyroid. This study aims to assess the prevalence and profile of thyroid disorders in patients with type 1 diabetes mellitus. Materials and Methods: 150 patients with type 1 diabetes mellitus presenting to the OPD of Department of general medicine, Owaisi Hospital, Deccan Medical College, Hyderabad over 1 year were included in the study. The thyroid hormone profile and presence of thyroid peroxidase antibodies were estimated. Results: The most common thyroid disorder observed in present study is hypothyroidism. Amongst the ones who were tested positive of thyroid peroxidase antibodies, most of them were hypothyroid. No cases of hyperthyroidism were observed in present study. Conclusion: patients with T1DM are at increased risk of developing other autoimmune endocrinological conditions such as autoimmune thyroid disorders. Screening for thyroid disorders in T1DM patients and their timely management will prevent complications related to dysregulated thyroid hormone and glucose metabolism. Keywords: Thyroid, hypothyroid, autoimmunity, type 1 diabetes mellitus.

Page No: 370-373 | Full Text

 

Original Research Article

TO ANALYSING PLASMA D-DIMER'S PERFORMANCE AS A FIRST DIAGNOSTIC BIOMARKER FOR CEREBRAL VENOUS THROMBOSIS

http://dx.doi.org/10.5530/ijmedph.2024.2.73

Rajesh Kumar Palaparthi, Lalitha Palaparthi, Surekha Kadamati, Purnima B Potharlanka

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Background: Compared to other common causes of stroke, cerebral venous and dural sinus thrombosis is a rare disease that can be hard to spot. General cerebrovascular thrombosis and symptoms that aren't linked to a stroke can both show up. Materials and Method: This case-control study looked at people from both Department of General Medicine, Government Siddhartha Medical College, Vijayawada, Andhra Pradesh, India. The Patients were registered one at a time from March 2023 to February 2024 of the same year, after signing forms giving their permission. All of the patients had cerebral venous thrombosis, which was clinically suspected. Results: The current results showed that the levels of D-dimer were very different between the cases and the controls. Using the assay's set criteria, 44 patients were also found to have a positive test result, which is the same as 14% of the control group. This result is the same as the one from the study that looked at 54 straight people who had headaches that might have been caused by CVT. All of the patients in the emergency room had D-dimer level tests done before they got brain CT or MRI scans. Out of the 54 people who took part in the study, 10 of the 12 with CVT had higher amounts of D-dimer. Conclusion: Finally, these findings show that D-dimer tests can be a useful way to find out if someone has CVT, especially if they have acute or subacute disease. Keywords: Brain venous thrombosis, diagnostic biomarker, plasma D-Dimer.

Page No: 374-378 | Full Text

 

Original Research Article

ACUTE ALUMINIUM PHOSPHIDE POISONING AND HYPERGLYCEMIA: A POSSIBLE WARNING SIGN FOR PROGNOSIS

http://dx.doi.org/10.5530/ijmedph.2024.2.74

Surekha Kadamati, Purnima B Potharlanka, Rajesh Kumar Palaparthi, Lalitha Palaparthi

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Background: Aluminum phosphide is a pesticide that is often used to keep grain holding areas clean. It is possible to buy AlP in the form of 3 g pills. There are 56% AlP and 44% ammonium carbonate in each pill. Materials and Methods: We did a prospective case-control study in the Department of General Medicine, Government Siddhartha Medical College, Vijayawada, Andhra Pradesh, India. People who were taken to the hospital because they were poisoned by AlP from a single drug were part of this study. The study began on February 2023 to January 2024. 45 people with a normal body mass index who had not been diagnosed with diabetes mellitus before began the study. The patient's or their family's information about the exposure agent was used to make the determination. Result: Phosphorus overdose happens quickly after AlP is eaten, and most people die within the first 12 to 24 hours, mostly from heart problems. The death rate from AlP overdose is said to be between 60% and 80%, according to reports. The numbers we have for this case series match these numbers. When AlP comes into contact with water, a very deadly gas called phosphine is released. One way that phosphine is harmful is by making free radicals and stopping biochemical enzymes like cytochrome-C oxidase from working. In a rabbit model of AlP poisoning, organs were looked at and the liver, heart, and kidneys all showed clear signs of degeneration. When people are exposed to AlP, it can cause problems in many organs. Conclusion: There needs to be more research done to find out if hyperglycemia-lowering medicine could help treat AIP poisoning. Keywords: Hyperglycemia, aluminium phosphide poisoning, potential prognostic factor.

Page No: 379-382 | Full Text