Background: To achieve the two principal objectives, the concept of Trisu–tra and Bija Catustaya has been designed by A – ca–rya Caraka and A – ca–rya Susruta respectively, Vya–dhi is the one among them. Homeostasis of the components of life maintains health whereas the imbalance of same leads to disease. Ayurveda analyses Vya–dhi and its Vargikarana to facilitates easy understanding of Vya–dhi as well as shows the path for further treatment aspects. Without the knowledge of Vya–dhi Vargikarana, it is futile to achieve the Savikalpa Jña– na. Objectives: Evaluation of disaster affected diseases with Vya–dhi Vargikarana. Materials and Methods: For the survey study, the affected places of Drought disaster events were visited, observed and surveyed through face to face. To collect the data a modified general case proforma was prepared with the help of disaster management faculty. For each event sample of minimum 100 affected people have been incorporated to enlist the major diseases in order to classify them under Vya–dhi Vargikarana. Results: The following Vya–dhis observed under Drought disaster, population are more vulnerable to GI Diseases, RT Diseases, UT Diseases, Nutritional Deficiency, Skin Diseases, Sun stroke and Leucorrhoea. There is a more chance of getting following Vya–dhi Vargikarana in Drought viz., Nija, A – gantuja, Sa–kha–gata, Ko–sthagata, Marmagata, Pittaja, Dwandvaja, and Sannipa–taja are highly Significant with p = .001. Conclusion: Disaster directly impacts the health of the population. In the present study, major observed Vya–dhi has been enlisted. A – gantuja, Sa–riria–ka – Ma–nasika, Sa–kha–gata, Ko–sthagata and Sannipa–taja are the common Vargikarana.