The ultimate goal of any oral therapeutic procedure is to protect and maintain the patient’s natural dentition for his or her lifetime. A recent innovation in dentistry is the preparation and use of platelet-rich plasma (PRP), a concentrated suspension of the growth factors found in platelets. These growth factors are involved in wound healing and are postulated as promoters of tissue regeneration. PRP is a new application of tissue engineering, biotechnology and a rapidly developing area for clinicians and researchers today. In real terms, PRP is just a volume of autologous plasma that has a platelet concentration above baseline. It is a storage vehicle for growth factors, especially which primarily influence bone regeneration. Because of its newness, there is a potential for misunderstanding, misuse, and application of what the practitioner may incorrectly think is PRP. Moreover, since this is an autologous preparation, any concerns regarding disease transmission and immunogenic reactions regarding allograftic and xenograftic preparations can be eliminated.