Aims and Objectives: To determine efficacy of analgesia of Analgesic drugs +Interferential Therapy (IFT) or without IFT. Material and Methods: The 80 eligible patients (30 male, 50 female) of acute and chronic low back pain were assigned to 5 groups (Grp), i.e., Grp A, B, C, D and E. The Orthopedician prescribed tablet Xenodol (Aceclofenac 100mg + Paracetamol 500mg 1 BD for 7 days) for Grp A, tablet Patrol (Tramadol 37.5mg + Paracetamol 325mg) 1 BD for 7 days) for Grp B, IFT 25 - 100Hz application at lumbar region for 15 min daily for 7 days for Grp C, tablet Xenodol of same dose with IFT 25 - 100Hz application for 7 days for Grp D and tablet Patrol of same dose with IFT 25 - 100Hz application for 7 days for Grp E patients. Eligible patients pain were assessed twice, i.e., pre-treatment and post-treatment, by SF-LF-MPQ (Short Form-Long Form McGill Pain Questionnaire’s Rating Index. Results: The post-treatment mean±SD was 1.3±0.9, 1.4±1.5, 1.6±0.85, 1±0.73, 0.93±1.16for Grp A, B, C, D and E respectively, while the pre-treatment pain intensity score mean±SD was 1.9±0.5, 2.4±1.1, 2.13±0.8, 2.25±0.9, 2.25±1.1 for Grp A,B,C,D,E respectively. The differences was statistically significant, i.e. (P < 0.05) 0.03856, 0.03601, 0.0002027, 0.002136 of Grp A, B, D, E respectively and insignificant, i.e. (P > 0.05) was 0.06603 for Grp C. Conclusion: Tablet Xenodol (Aceclofenac+Paracetamol) and tablet Patrol (Tramadol+Paracetamol)alone showed efficacy in pain reduction, while when the tablets Xenodol and tablet Patrol of same doses given with IFT 25 - 100Hz application at lumbar regionin Grp D and Grp E the pain reduction was highly significant than the medication alone groups, i.e., for Grp A, B, C.