Background: Diabetic neuropathy (DN) can affect any part of the nervous system and should be suspected in all patients who have had diabetes for more than 5 years. Family physicians (FPs) can play an important role with the care and education of people with diabetes. They can augment the knowledge and motivate the diabetics to acquire a healthy life style, which would further lead to a good glycemic control providing protection from the chronic complications. Lack of compliance with the guidelines on the part of the diabetic subjects, indicates deficiencies in the FPs’ knowledge, implementation techniques, and attitude problems. Therefore, the present study was conducted to assess FPs’ knowledge, attitude, and practice regarding DN for further educational interventions that will improve their quality of care for diabetic patients in family practice centers. Materials and Methods: The study population was 60 FPs working in family practice centers affiliated to Suez Canal University Hospitals. The questionnaire composed of three groups of questions to collect data for evaluation of knowledge, attitude, and practice; two written patient problems to assess their practice and two questions to assess barriers and recommendations of physicians. To pass the evaluation; 50, 80, and 60% were the cut off points to pass the evaluation for knowledge, attitude, and practice, respectively. Results: 48.3, 66.7, and 43.3% of the evaluated FPs passed the knowledge, attitude, and practice assessment, respectively. Eighty-five percent of physicians felt that they need more knowledge and training in DN management. Physicians’ qualification (P = 0.037) was a significant variable in passing the knowledge test, but qualification and experience years (P = 0.007 and 0.035, respectively) were significant variables in passing the practice test. There was a positive significant (P = 0.021) correlation between practice and knowledge score. Postgraduate knowledge accounts the majority (78.3%) as a source of information about DN. Providing physicians with standardized guidelines (81.7%), continuous medical education seminars (76.7%) and training courses (76.7%) came at the top of physician’s recommendations to improve DN care by FPs. Conclusion: This study has identified the need for improvement in family medicine physician practices for treating and educating diabetics and recommended that awareness and educational programs are necessary to update the FPs on screening, effective treatment of diabetes and prevention of DN.