Hepatitis A Virus Meningoencephalitis

Submitted by sys1 on Fri, 11/11/2016 - 16:05
International Journal of Medicine and Public Health,2016,6,4,209-209.
Published:November 2016
Type:Letter to Editor

Hepatitis A Virus Meningoencephalitis

Sedat Işıkay*1, Halil Kocamaz2, Olcay Güngör1, Serkan Kırık1

1Department of Pediatric Neurology, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey

2Department of Pediatric Gastroenterology, Pamukkale University, Denizli, Turkey



A 10-year-old girl presented with a one-week history of abdominal pain, nausea and dark urine. On admission, she was icteric and drowsy with palpable liver 2 cm below the costal margin. The laboratory tests revealed elevated liver function tests with an aspartate aminotransferase level of 349 IU/L (8-40 IU/L), an alanine aminotransferase level of 1327 IU/L (7-56 IU/L), a gamma glutamyl transferase level of 370 U/L (9-24 U/L), an alkaline phosphatase level of 325 IU/L (30-100 IU/L), a total bilirubin of 3.3 mg/dL (0.2-1.2 mg/dL) and direct bilirubin of 2.2 mg/dL (0.1-0.4 mg/dL). The patient’s plasma ammonia level was 67 mg/dL (15-45 mg/dL). Values of Prothrombin Time (14 seconds), activated Partial Thromboplastin Time (35 seconds) and International normalized ratio (1.12) were within normal ranges. In investigations, an immunoglobulin M (Ig M) antibody against hepatitis A virus (HAV) was positive with negative serological markers for hepatitis B and C viruses. The Widal and Weil Felix tests were negative.Read more...

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